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Cell-type-specific functions of the Hippo pathway. The Hippo pathway and YAP/TAZ play key roles in hepatocytes, cholangiocytes, endothelial cells, and stellate cells within the liver, which are depicted here in a representation of a hepatic lobule. Shared features include that YAP/TAZ regulate liver regeneration in the context of the stellate cell, hepatocyte, and cholangiocyte and are involved in cancers that originate from liver bile duct cells, hepatocytes, and endothelial cells.
