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. Author manuscript; available in PMC: 2021 Nov 16.
Published in final edited form as: Annu Rev Pathol. 2020 Nov 24;16:299–322. doi: 10.1146/annurev-pathol-030420-105050

Figure 3.

Figure 3

Regulation of the Hippo pathway. (a) Summary of inputs and outputs of the Hippo pathway that converge on YAP/TAZ. Schematics of regulation of the Hippo pathway by (b) energy levels and AMPK, (c) high glucose, (d) the mevalonate pathway, (e) bile acids, (f) GPCRs and their ligands, and (g) mechanical forces. Components in red denote the core proteins of the Hippo pathway, and components in green are regulators of the Hippo pathway that are important in the liver. Blue components denote regulators identified in Drosophila or in mammals that have not yet been tested in the liver but are discussed in this review.