Table 4.
Comparison of Characteristics of Cases with Spondyloarthritis/HLA-B27-associated Acute vs Chronic Anterior Uveitis
| Characteristic | Acute anterior uveitis* | Chronic anterior uveitis† | P-value |
|---|---|---|---|
| Number cases | 155 | 29 | |
| Demographics | |||
| Age, median, years (25th 75th percentile) | 37 (29, 46) | 37 (35, 40) | 0.78 |
| Gender (%) | 0.17 | ||
| Men | 52 | 65 | |
| Women | 48 | 35 | |
| Race/ethnicity (%) | 0.09 | ||
| White, non-Hispanic | 73 | 86 | |
| Black, non-Hispanic | 4 | 4 | |
| Hispanic | 0 | 0 | |
| Asian, Pacific Islander | 16 | 0 | |
| Other | 3 | 4 | |
| Missing/unknown | 4 | 6 | |
| Uveitis History | |||
| Laterality (%) | <0.001 | ||
| Unilateral | 56 | 79 | |
| Unilateral, alternating | 43 | 0 | |
| Bilateral | 1 | 21 | |
| Ophthalmic examination | |||
| Keratic precipitates (%) | 0.79 | ||
| None | 40 | 45 | |
| Fine | 55 | 48 | |
| Other | 5 | 7 | |
| Anterior chamber cells (%) | 0.52 | ||
| ≤2+ | 64 | 79 | |
| >2+ | 36 | 21 | |
| Hypopyon (%) | 10 | 14 | 0.51 |
| Iris (%) | 0.19 | ||
| Normal | 65 | 52 | |
| Posterior synechiae | 35 | 48 | |
| Intraocular pressure (IOP), involved eyes | 14 (13, 17) | 15 (13, 18) | 0.31 |
| Median, mm Hg (25th, 75th percentile) | |||
| Vitreous cells (%) | 0.52 | ||
| Grade 0 | 68 | 66 | |
| >½+ | 32 | 34 | |
| Systemic disease (%) | |||
| Spondyloarthritis (axial or peripheral) | 48 | 72 | 0.03 |
| Inflammatory bowel disease | 3 | 7 | |
| Laboratory | |||
| Positive HLA-B27 (%) | 98 | 97 | 0.61 |
*
Includes 113 cases with recurrent acute anterior uveitis and 42 cases with single episode of acute anterior uveitis.
†
Includes 8 cases with history or acute anterior uveitis and crescendo pattern into chronic anterior uveitis.