Table 5.

Classification Criteria for Spondyloarthritis/HLA-B27-associated Anterior Uveitis

Criteria

1. Evidence of anterior uveitis

a. anterior chamber cells

b. if anterior vitreous cells are present, severity is less than anterior chamber inflammation

AND either (both #2 and #3) OR #4

2. Characteristic uveitis course

a. Acute or recurrent acute, unilateral or unilateral alternating course OR

b. Chronic course with a history of a recurrent acute, unilateral or unilateral alternating course evolving into chronic course

AND

3. ASAS-defined spondyloarthritis (axial or peripheral) and/or HLA-B27-positive

OR

4. Chronic uveitis with both ASAS-defined spondyloarthritis (axial or peripheral) AND HLA-B27-positive

Exclusions

1. Positive serology for syphilis using a treponemal test

2. Evidence of sarcoidosis (either bilateral hilar adenopathy oi chest imaging or tissue biopsy demonstrating non-caseating granulomata)

3. Aqueous specimen PCR† positive for cytomegalovirus, Herpes simplex virus or Varicella zoster virus

^*ASAS criteria for axial spondyloarthritis or peripheral spondyloarthritis.^7,8 See Tables 1 and 2.

^†PCR = polymerase chain reaction.