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. 2021 Nov 4;17(11):e1010032. doi: 10.1371/journal.ppat.1010032

Fig 6. CTCF regulates efficient differentiation-dependent HPV18 late promoter activation.

Fig 6

The 5’ end of each viral transcript was identified and the distribution shown in violin plots in (A) undifferentiated and (B) differentiated keratinocytes containing HPV18 (blue and green, respectively) and ΔCTCF-HPV18 (red and purple, respectively) episomes. Data distribution are shown by the kernel shape and median indicated with a vertical solid line. The widest sections of each violin plot indicates the highest probability of promoter usage within that region of the HPV18 genome. The shape of the distribution indicates the concentration of data points in a particular region; the steeper the side of each bubble indicates a greater concentration of data points. ns, non significant; ****p<0.0001 (Fisher’s test).

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