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. Author manuscript; available in PMC: 2022 Jan 29.
Published in final edited form as: Nat Cancer. 2021 Jul 29;2(9):891–903. doi: 10.1038/s43018-021-00234-4

Extended Data Fig. 7. Combination of cabozantinib and nivolumab promotes systemic T cell responses.

Extended Data Fig. 7

a, PBMCs from eight paired pre- and post-treatment samples were assayed by a 27-marker CyTOF panel dedicated to phenotyping T cells. FlowSOM algorithm was employed to generate 30 metaclusters which were then annotated into 23 final clusters. Scaled expression profile for each of the clusters are shown in the heatmap. b, Radar plot showing average fold changes for the abundance of every T cell subtype. Color legends apply to both panels A and B. P-values (edgeR) are annotated. Abbreviations: CM, central memory, DNT, double-negative T; DPT, double-positive T; Eff, effector; EM, effector memory; EX, exhaustion marker positive; N, naïve; NK, natural killer; UA, unassigned.