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. 2021 Jun 24;1(3):100037. doi: 10.1016/j.xjidi.2021.100037

Table 10.

Topics of Investigation Required for the Myotonometer to Serve as a Valid Response Measure Instrument in the Management of Sclerotic cGVHD

Serial Number Topics of Investigation Relevant Studies
1 Intraoperator and interoperator reliability Dellalana et al., 2019.
2 Ability to discriminate obvious patients with sclerotic from healthy patients Chen et al., 2019a.
3 Ability to discriminate patients with obvious sclerosis from post-HCT controls without clinical evidence of sclerosis The current study
4 Determination of the optimal parameter or combination of parameters for topic of investigation 3 (above) The current study
5 Selection of an efficient clinical protocol that future studies and clinical practice can use for patient-level investigation Chen et al., 2019a.
The current study found that a supine-only protocol maintained discriminatory ability.
6 Determination of whether individual sites are more or less useful than averages across sites. Determination of how individual sites correlate with the clinical appreciation of sclerosis at or near those sites The current study provides the typical ranges of parameter values that may be used to design future studies.
7 Consistency of longitudinal measurements with clinical response Baker et al., 2021
8 Ability to detect subclinical disease Future study

Abbreviations: cGVHD, chronic graft-versus-host disease; HCT, hematopoietic cell transplantation.