Table 5.
LASSO Regression Coefficients and AUCs of 10 Repeats of 3-Fold Cross-Validation for Averages across All the 18 Measured Sites (n for Sclerotic cGVHD = 13, n for Post-HCT Controls = 11) and Averages across the 12 Supine Sites (n for Sclerotic cGVHD 15, n for Post-HCT Controls 11)
| LASSO Regression Models for Averages across All the 18 Measured Sites | |||||||
|---|---|---|---|---|---|---|---|
| Rep | AUC without Overfit Correction (95% CI) | AUC with Overfit Correction (95% CI) | Parameters Selected by Model |
||||
| Frequency | Relaxation Time | Stiffness | Creep | Decrement | |||
| 1 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.722 | –0.050 | — | — | — |
| 2 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.592 | –0.030 | — | — | — |
| 3 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.300 | — | — | — | — |
| 4 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.456 | –0.008 | — | — | — |
| 5 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.592 | –0.030 | — | — | — |
| 6 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.524 | –0.019 | — | — | — |
| 7 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.904 | –0.076 | — | — | — |
| 8 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.040 | — | — | — | — |
| 9 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.383 | — | — | — | — |
| 10 | 0.909 (0.786–1) | 0.871 (0.641–0.998) | 1.592 | –0.030 | — | — | — |
| LASSO Regression Models for Averages across the 12 Supine Sites | |||||||
|---|---|---|---|---|---|---|---|
| Rep | AUC without Overfit Correction (95% CI) | AUC with Overfit Correction (95% CI) | Parameters Selected by Model |
||||
| Frequency | Relaxation Time | Stiffness | Creep | Decrement | |||
| 1 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 1.161 | –0.139 | — | — | — |
| 2 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 0.970 | –0.014 | — | — | — |
| 3 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 1.040 | –0.061 | — | — | — |
| 4 | 0.867 (0.721–1) | 0.777 (0.429–0.978) | 1.627 | –2.367 | –0.542 | 1.500 | –0.095 |
| 5 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 1.005 | –0.038 | — | — | — |
| 6 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 1.161 | –0.139 | — | — | — |
| 7 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 1.040 | –0.061 | — | — | — |
| 8 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 1.161 | –0.139 | — | — | — |
| 9 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 0.923 | — | — | — | — |
| 10 | 0.873 (0.725–1) | 0.778 (0.429–0.978) | 1.040 | –0.061 | — | — | — |
Abbreviations: AUC, area under the curve; cGVHD, chronic graft-versus-host disease; HCT, hematopoietic cell transplantation; LASSO, least absolute shrinkage and selection operator; Rep, repetition.