Table 7.
Representative Combinations for Parameters Selected by LASSO Regression as the Most Important Variables in Differentiating Patients with Sclerotic cGVHD from Post-HCT Controls for Each Site
|
Sites |
Frequency | Relaxation Time | Stiffness | Creep | Decrement | AUC with Overfit Correction (95% CI) |
|---|---|---|---|---|---|---|
| Abdomen L | + | + | + | + | 0.884 (0.674–0.996) | |
| Abdomen R | + | + | + | 0.902 (0.737–0.999) | ||
| Upper Arm L | + | + | 0.773 (0.431–0.981) | |||
| Upper Arm R | + | + | 0.773 (0.422–0.983) | |||
| Chest L | + | + | + | + | 0.801 (0.437–0.992) | |
| Chest R | + | 0.829 (0.546–0.992) | ||||
| Upper back L | + | + | 0.840 (0.533–0.994) | |||
| Upper back R | + | + | 0.756 (0.358–0.987) | |||
| Shin L | + | + | 0.855 (0.606–0.992) | |||
| Shin R | + | + | + | 0.761 (0.407–0.978) | ||
| Calf L | + | 0.741 (0.404–0.964) | ||||
| Calf R | + | + | + | + | + | 0.780 (0.411–0.986) |
| Lower back L | + | + | + | 0.812 (0.445–0.988) | ||
| Lower back R | + | + | + | + | 0.740 (0.327–0.979) | |
| Shoulder L | + | + | + | + | + | 0.725 (0.381–0.955) |
| Shoulder R | + | + | + | + | + | 0.757 (0.392–0.981) |
| Dorsal forearm L | + | + | 0.782 (0.427–0.985) | |||
| Dorsal Forearm R | + | + | 0.846 (0.559–0.995) | |||
| Average across all sites | + | + | 0.871 (0.641–0.998) | |||
| Average across supine sites | + | + | 0.778 (0.429–0.978) |
Abbreviations: AUC, area under the curve; cGVHD, chronic graft-versus-host disease; CI, confidence interval; HCT, hematopoietic cell transplantation; L, left; LASSO, least absolute shrinkage and selection operator; R, right.
Representative: of 10 repetitions, the most commonly selected combination of parameters for each site is shown.