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. 2021 Nov 16;2021(11):CD012775. doi: 10.1002/14651858.CD012775.pub2

Gao 2013.

Study characteristics
Methods Randomised, cross‐over, self‐control study with 2 arms
  • comparison of palonosetron + dexamethasone vs granisetron + dexamethasone


Recruitment period: n.r.
  • 84 patients randomised


Masking: n.r.
Baseline patient characteristics: n.r.
Follow‐up: n.r.
Participants Inclusion criteria: n.r.
Exclusion criteria: n.r.
Mean/median age (range), years: n.r.
Gender: n.r.
Tumour/cancer type: n.r.
Chemotherapy regimen: cisplatin‐based chemotherapy
Country: n.r.
Interventions Cross‐over study
Experimental: arm A: palonosetron
Day 1: palonosetron 0. 25 mg i.v. + dexamethasone 10 mg i.v.
Day 2: dexamethasone 10 mg i.v.
Day 3: palonosetron 0. 25 mg i.v. + dexamethasone 10 mg i.v.
Experimental: arm B: granisetron
Days 1 to 3: granisetron 3 mg i.v. + dexamethasone 10 mg i.v.
Outcomes not reported
Notes
  • conference abstract

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: randomised trial but method of randomisation not described
Allocation concealment (selection bias) Unclear risk Comment: allocation concealment not reported
Blinding of participants and personnel (performance bias)
Blinding of participants Unclear risk Comment: blinding not reported
Blinding of participants and personnel (performance bias)
Blinding of personnel Unclear risk Comment: blinding not reported
Blinding of outcome assessment (detection bias)
Subjective outcomes (Patient reported outcomes) Unclear risk Comment: blinding not reported
Incomplete outcome data (attrition bias)
Subjective outcomes (Patient reported outcomes) Unclear risk Comment: no outcomes reported
Selective reporting (reporting bias) Unclear risk Comment: conference abstract, not evaluable
Other bias Unclear risk Comment: conference abstract, not evaluable