Jantunen 1992.

Study characteristics
Methods	Randomised, prospective, cross‐over study with 2 arms comparison of ondansetron + dexamethasone vs tropisetron + dexamethasone Enrolment period: n.r. 47 patients entered Masking: open‐label Baseline patient characteristics: reported Follow‐up: yes
Participants	Inclusion criteria outpatients and inpatients designated to receive 2 similar courses of non‐cisplatin‐containing chemotherapy separated by at least 14 days Exclusion criteria brain metastases signs of bowel obstruction experienced vomiting within 12 h before start of the study Median age, years: 58.3 in males, 49.5 in females Gender: male (14) + female (33) Tumour/cancer type: solid tumour (breast, lung, melanoma, other) Chemotherapy regimen: non‐cisplatin‐containing chemotherapy (CNF, CMF, CEF, VAC, carboplatin‐containing, DTIC‐containing, epirubicin‐containing, MTX‐5‐FU, MMM) Country: n.r.
Interventions	Cross‐over study Experimental: arm A: ondansetron 8 mg ondansetron + 10 mg dexamethasone (loading dose of ondansetron was followed by 8 mg ondansetron given orally twice at 8‐h intervals) Experimental: arm B: tropisetron 5 mg tropisetron + 10 mg dexamethasone
Outcomes	control of vomiting during first 24 h was scored as total: no vomiting partial: 1 to 4 vomits failure: more than 4 vomits
Notes	no information regarding sponsor and clinical trial registration reported study authors did not provide disclosure of potential conflicts of interest
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Comment: randomised trial but method of randomisation not reported
Allocation concealment (selection bias)	Unclear risk	Comment: allocation concealment not reported
Blinding of participants and personnel (performance bias) Blinding of participants	High risk	Comment: open‐label
Blinding of participants and personnel (performance bias) Blinding of personnel	High risk	Comment: open‐label
Blinding of outcome assessment (detection bias) Subjective outcomes (Patient reported outcomes)	High risk	Comment: patients and personnel were not blinded towards the intervention and therefore might influence subjective outcomes analysis
Incomplete outcome data (attrition bias) Subjective outcomes (Patient reported outcomes)	Low risk	Quote: "thirty‐nine patients were evaluable for cross‐over analysis"
Selective reporting (reporting bias)	Low risk	Comment: all outcome measures were reported in the results section
Other bias	Low risk	Comment: no information to suggest other sources of bias