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. 2021 Nov 16;2021(11):CD012775. doi: 10.1002/14651858.CD012775.pub2

Stewart 1996.

Study characteristics
Methods Randomised trial with 2 arms
  • comparison of granisetron + dexamethasone vs ondansetron + dexamethasone


Recruitment period: n.r.
Enrolled/randomised patient number: n.r.
Masking: double‐blind
Baseline patient characteristics: n.r.
Follow‐up: n.r.
Participants Inclusion criteria: n.r.
Exclusion criteria: n.r.
Mean/median age (range), years: n.r.
Gender: n.r.
Tumour/cancer type: n.r.
Chemotherapy regimen: cisplatin
Country: n.r.
Interventions Experimental: arm A: granisetron
granisetron + dexamethasone (8 mg i.v., then treatment 4 mg t.d.s. for 3 days afterwards)
Experimental: arm B: ondansetron
ondansetron + dexamethasone (8 mg i.v., then treatment 4 mg t.d.s. for 3 days afterwards)
Outcomes
  • not reported

Notes
  • poster presentation

Risk of bias
Bias Authors' judgement Support for judgement
Random sequence generation (selection bias) Unclear risk Comment: randomised study but method of randomisation not described
Allocation concealment (selection bias) Unclear risk Comment: allocation concealment not reported
Blinding of participants and personnel (performance bias)
Blinding of participants Low risk Comment: double‐blind
Blinding of participants and personnel (performance bias)
Blinding of personnel Low risk Comment: double‐blind
Blinding of outcome assessment (detection bias)
Subjective outcomes (Patient reported outcomes) Low risk Comment: both patients and personnel were blinded towards the intervention and thus had no influence on outcome assessment
Incomplete outcome data (attrition bias)
Subjective outcomes (Patient reported outcomes) Unclear risk Comment: not reported
Selective reporting (reporting bias) Unclear risk Comment: not evaluable, conference abstract only
Other bias Unclear risk Conference abstract, not evaluable