Table 3.
Summary of clinical trials using Punica granatum (pomegranate) in dermatologic disorders.
| Striae distensae | Oil-in-water cream containing Punica granatum seed oil and Croton lechleri resin extract | 20 | Non-randomized study | Once daily on the hip area/6 weeks | Improvement of striae , dermis thickness, hydration and elasticity values. | [65] |
|
| ||||||
| Effects on skin biophysical parameters | (i) Fixed Polypodium leucotomos/pomegranate combination (PPmix®) (ii) Polypodium leucotomos alone (Fernblock®) |
40 | Double‐blind, RCT | 480 mg daily/3 months | Fixed Polypodium leucotomos/pomegranate combination improved skin biophysical parameters more than Polypodium leucotomos alone in adult Caucasians. | [66] |
|
| ||||||
| Facial photodamage | (i) Vitaphenol skin cream containing green and white teas, mangosteen, and pomegranate extract (ii) Placebo cream |
20 | RCT | Twice daily/60 days | Combination of three antioxidants had an additive efficacy in improvement of facial photodamage. | [67] |
|
| ||||||
| Ultraviolet-induced pigmentation | (i) High-dose POMx (ii) Low-dose POMx (iii) Placebo |
37 | Double‐blind, RCT | (i) 200 mg daily ellagic acid (2 tablets daily)/4 weeks (ii) 100 mg daily ellagic acid (2 tablets daily)/4 weeks (iii) 0 mg daily ellagic acid (2 tablets daily)/4 weeks |
Orally ellagic acid-rich pomegranate extract had a protective effect against slight sunburn due to UV irradiation. | [68] |
|
| ||||||
| Skin erythema and melanin | (i) Topical microemulsion (O/W) of POMx (ii) Placebo microemulsion (without extract) |
11 | Single-blinded, clinical study | At night on cheeks/12 weeks | Active microemulsion revealed a significant effect on skin erythema and melanin (p < 0.05). | [69] |
|
| ||||||
| UVB-induced erythema and changes the skin microbiome | (i) POMx (ii) PJ (iii) Placebo |
74 | Open-label RCT | (i) 1000 mg daily/12 weeks (ii) 8 oz daily/12 weeks (iii) 8 oz daily/12 weeks |
Daily oral pomegranate intake can be helpful to protect against UVB-induced skin damage. | [70] |
|
| ||||||
| Diabetic foot ulceration | (i) Control (ii) Punica granatum extract (iii) Propolis extract |
60 | Pretest/posttest control quasi- experimental design | — | Punica granatum and Propolis are an effective extract to control the diabetic foot ulceration. | [71] |
|
| ||||||
| Non-healing chronic ulcer | 2% (w/w) PGHF | 1 | Case study | Once a day/10 weeks | PGHF (an alternative agent in wound healing treatment). | [72] |
|
| ||||||
| Herpes zoster pain | Hot water extracts of a herbal formula containing Ganoderma lucidum and WTMCGEPP (Wisteria floribunda 0.38, Trapa natans 0.38, Myristica agrans 0.38, Coix lachryma-jobi 0.75, cultivated Ganoderma lucidum 0.75, Elfuinga applanata 0.38, tissue cultured Panax ginseng 0.3, and Punica granatum 0.38: numerals designate dry weight gram/dose) | 5 | Pilot clinical trial | Several doses daily | Increase in treatment response. | [73] |
|
| ||||||
| Dandruff | Antidandruff shampoo (Zinc-PCA and piroctone olamine in combination with Punica granatum L., Rosmarinus officinalis L., Matricaria chamomilla L., Urtica dioica L., Mentha piperita L., and Salvia officinalis L. methanolic extracts) | 30 | Clinical trial | 3 times a week/2 months | Reduction of dandruff with low side effects. | [74] |