TABLE 1.

Studies with animal models and human patients included in the systematic review.

Animal model/human trials	Number of studies	Percentage of total (%)	References
Rodents	44	46.31	Lovett et al. (2010), Song et al. (2010), Harrington et al. (2011), Hibino et al. (2011), Hwang et al. (2011), Assmann et al. (2012), Quint et al. (2012), De Valence et al. (2013), Conconi et al. (2014), Lee et al. (2014), Tara et al. (2014), Udelsman et al. (2014), Itoh et al. (2015), Tara et al. (2015), Wu et al. (2015), Fukunishi et al. (2016), Gui et al. (2016), Hibino et al. (2016), Jiang et al. (2016), Khosravi et al. (2016), Tondreau et al. (2016), Wang et al. (2016), Yang et al. (2016), Li et al. (2017), Maxfield et al. (2017), Negishi et al. (2017), Best et al. (2018), Lee et al. (2018), Li et al. (2018), Qin et al. (2018), Shafiq et al. (2018), Wu et al. (2018), Xu et al. (2018), Aubin et al. (2019), Bai et al. (2019), Best et al. (2019), Katsimpoulas et al. (2019), Liu et al. (2019), Ran et al. (2019), Shi et al. (2019), Smith et al. (2019), Sologashvili et al. (2019), Yamanami et al. (2019)
Ovine	19	20	Cummings et al. (2012), Koenneker et al. (2012), Tillman et al. (2012), Meier et al. (2014), Stacy et al. (2014), Row et al. (2015), Aper et al. (2016), Fukunishi et al. (2016), Koobatian et al. (2016), Syedain et al. (2016), Fukunishi et al. (2017), Ju et al. (2017), Pepper et al. (2017), Ong et al. (2017a), Madhavan et al. (2018), Valencia-Rivero et al. (2018), Weber et al. (2018), Alessandrino et al. (2019), Wolf et al. (2019)
Pigs	13	13.68	Quint et al. (2011), Mrówczyński et al. (2014), Koens et al. (2015), Mahara et al. (2015), Pellegata et al. (2015), Rothuizen et al. (2016), Dahan et al. (2017), Iacobazzi et al. (2018), Valencia-Rivero et al. (2018), Alessandrino et al. (2019), Itoh et al. (2019), Wang et al. (2019), Yeung et al. (2019)
Rabbits	7	7.37	Zhao et al. (2012), McIlhenny et al. (2015), Hu et al. (2017), Tseng et al. (2017), Jin et al. (2019a), Jin et al. (2019b), Kajbafzadeh et al. (2019)
Dogs	7	7.37	Matsumura et al. (2012), Aytemiz et al. (2013), Matsumura et al. (2013), Isayama et al. (2014), Ma et al. (2017), Furukoshi et al. (2019), Jang et al. (2020)
Human patients	3	3.16	Sugiura et al. (2018), Herrmann et al. (2019), Kirkton et al. (2019)
Baboons	2	2.11	Prichard et al. (2011), Syedain et al. (2017)