TABLE 3.

Summary of the advantages and disadvantages of animal models analyzed.

Animal model	Advantages	Disadvantages
Rodents	Low cost	Cardiovascular physiology
	Biocompatibility and cell infiltration studies	Thrombogenicity mechanisms
	Genetically modified strains	Hemostasis mechanisms
Ovine	Thrombogenicity mechanisms	Hypercoagulability
	Fibrinolysis system
	Endothelialization and neointimal formation
Porcine	Cardiovascular anatomy	Grow rapidly
	Translational studies	Hypercoagulability
Rabbits	Thrombogenicity mechanisms	Vascular physiology
	Heritable disease models
Canine	Anatomy extensively studied	Thrombogenicity mechanisms
	Lack of spontaneous endothelialization	Potent fibrinolytic system
		Ethical aspects
Nonhuman primates	Physiology	High cost
	Cardiovascular anatomy	Ethical considerations
	Thrombogenicity mechanisms