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. 2021 Nov 3;14:763610. doi: 10.3389/fnmol.2021.763610

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Copyright © 2021 Li, Zhang, Xia, Niu and Zhou.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Diverse types of intercellular communications mediate the regulatory effects of ncRNAs on glioma angiogenesis in the tumor microenvironment. (A) The distribution and delivery of ncRNAs within the glioma microenvironment. (B) Delivery of ncRNAs from donor to recipient cells through the small EVs and medium/large EVs. (C) Transmission of ncRNAs between adjacent cells through GJIC based on gap junctions and channels. (D) ncRNA regulation of soluble factors that mediate the interaction between donor and recipient cells.