Table 1.

miRNAs involved in the regulation of glioma angiogenesis.

miRNA	Mechanism of action	Effect on angiogenesis	References
miR-296	Target the hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) mRNA, leading to decreased levels of HGS and thereby reducing HGS-mediated degradation of the growth factor receptors VEGFR2 and PDGFR beta.	Promote	Wuerdinger et al. (2008)
miR-93	Promote angiogenesis by suppressing, at least in part, integrin-beta 8 expression.	Promote	Fang et al. (2011) and Tchaicha et al. (2011)
miR-675-5p	Interact with HIF-1 alpha mRNA and the RNA Binding Protein HuR in hypoxia-induced responses.	Promote	Lo Dico et al. (2016)
miR-124-3p	miR-124-3p/NRP-1/GIPC1 pathway.	Inhibit	Zhang et al. (2018)
miRNA-205	Suppress expression of VEGF-A by directly interacting with the putative miRNA-205 binding site at the 3′-UTR.	Inhibit	Yue et al. (2012)
miR-128	Suppress p70S6K1 and its downstream signaling molecules such as HIF-1 and VEGF expression.	Inhibit	Shi et al. (2012) and Adlakha and Saini (2014)