Table 4.

Outcomes of confidence rating and health effect assessment.

		Factors decreasing confidence					Factors increasing confidence
	Body of Evidence	Risk of Bias	Unexplained Inconsistency	Indirectness	Imprecision	Publication Bias	Magnitude	Dose Response	Residual Confounding	Consistency Across Species	Final Rating	Level of evidence for health effect
testis weight(g)	++++	↓	-	-	-	-	-	-	-	↑	++++	High
testes weight(g)	++++	↓	-	-	-	-	-	-	-	-	+++	Moderate
relative testis weight(% body weight)	++++	↓	↓	-	-	↓	-	-	-	↑	++	Inadequate
relative testes weight(% body weight)	++++	↓	-	-	-	-	-	-	-	-	+++	Inadequate
epididymis weight(g)	++++	↓	-	-	-	-	-	-	-	↑	++++	High
relative epididymis weight(% body weight)	++++	↓	-	-	-	-	-	-	-	↑	++++	High
ventral prostate weight(g)	++++	↓	-	-	-	-	-	-	-	↑	++++	High
prostate weight(g)	++++	↓	-	-	-	-	-	-	-	-	+++	Inadequate
relative ventral prostate weight(% body weight)	++++	↓	-	-	-	-	-	-	-	-	+++	Moderate
seminal vesicle weight(g)	++++	↓	-	-	-	↓	-	-	-	-	++	Low
anogenital distance(mm)	++++	↓	-	-	-	↓	-	-	-	↑	+++	Moderate
relative anogenital distance(% body length)	++++	↓	-	-	-	-	-	-	-	↑	++++	High
sperm count(×10⁶),	++++	↓	-	-	-	-	-	-	-	↑	++++	High
daily sperm production(×10⁶)	++++	↓	↓	-	-	-	-	-	-	↑	+++	Moderate
serum testosterone(ng/ml)	++++	↓	-	-	-	-	-	-	-	↑	++++	High
sperm motility(%)	++++	↓	-	-	-	-	-	-	-	-	+++	Moderate
abnormal sperm(%)	++++	↓	-	-	-	-	-	-	-	-	+++	Moderate
relative seminal vesicle weight(% body weight)	++++	↓	-	-	-	↓	-	-	-	-	++	Low