Table 2.
Characteristics of the included infants.
| n | Total cohort | No ROP | Any ROP | Severe ROP | Type 1 ROP |
|---|---|---|---|---|---|
| 152 | 119 | 33 | 20 | 6 | |
| Male, n (%) | 78 (51.3) | 65 (54.6) | 13 (39.4) | 9 (45.0) | 2 (33.3) |
| Gestational age (weeks) (median, range) | 30 (24–36) | 31 (24–36) | 28(24–32) | 27 (24–30) | 25 (24–29) |
| Birth weight (g) (median, range) | 1240 (408–2670) | 1335 (500–2670) | 825 (408–1340) | 770 (408–1340) | 736 (589–110) |
| SGA, n (%) | 37 (24.3) | 27 (22.7) | 10 (30.3) | 7 (35.0) | 2 (33.3) |
| Gestational diabetes, n (%) | 18 (11.8) | 14 (11.7) | 4 (12.1) | 2 (10) | 0 (0.0) |
| Hyperglycemia, n (%) | 30 (19.7) | 6 (5.0) | 24 (72.7) | 15 (75.0) | 4 (66.7) |
| Hyaline membrane disease* n (%) | 132 (86.8) | 101 (84.8) | 31 (93.9) | 18 (90.0) | 6 (100.0) |
| Bronchopulmonary dysplasia, n (%) | 43 (28.3) | 20 (16.8) | 23 (69.6) | 15 (75.0) | 6 (100.0) |
| Need of oxygen > 28 days, n (%) | 47 (30.9) | 22 (18.5) | 25 (75.8) | 17 (85.0) | 6 (100.0) |
| Days of mechanical ventilation (median, range) | 0 (0–86) | 0 (0–86) | 7 (0–82) | 17 (0–60) | 24 (0–60) |
| Days of oxygen supplementation (median, range) | 10 (0–226) | 8 (0–226) | 46 (1–221) | 72 (1–221) | 89 (41–221) |
| Thrombocytopenia** n (%) | 47 (30.9) | 33 (27.7) | 14 (42.4) | 10 (50.0) | 3 (50.0) |
| Prenatal steroids for pulmonary maturation n (%) | 139 (91.4) | 108 (90.8) | 31 (93.9) | 19 (95.0) | 5 (83.3) |
| Postnatal steroids n (%) | 7 (4.6) | 3 (2.5) | 4 (12.1) | 3 (15) | 3 (50.0) |
| Early red cell transfusion+ n (%) | 27 (17.8) | 10 (8.4) | 17 (51.5) | 13 (65.0) | 5 (83.3) |
| Total red cell transfusions (median, range) | 0 (0–13) | 0 (0–8) | 2 (0–13) | 4 (0–13) | 7 (0–9) |
| Anemia first week of life++ n (%) | 25 (16.4) | 11 (9.2) | 14 (42.4) | 10 (50.0) | 3 (50.0) |
| Persistent ductus arteriosus n (%) | 22 (16.4) | 14 (11.7) | 8 (24.2) | 5 (25.0) | 2 (33.3) |
| Peri and intraventricular hemorrhage+++ n (%) | 46 (30.3) | 29 (24.4) | 17 (51.5) | 14 (70.0) | 5 (83.3) |
| Furosemide n (%) | 38 (25.0) | 20 (16.8) | 18 (54.5) | 13 (65.0) | 4 (66.7) |
| Days of phototherapy (median, range) | 3 (0–15) | 3 (0–15) | 4 (0–9) | 4 (0–9) | 4 (2–7) |
| Early onset sepsis n (%) | 55 (36.2) | 38 (31.9) | 17 (51.5) | 13 (65.0) | 4 (66.7) |
| Late onset sepsis n (%) | 60 (39.5) | 37 (31.1) | 23 (69.6) | 15 (75.0) | 3 (50.0) |
| NEC n (%) | 8 (5.3) | 2 (1.7) | 6 (18.2) | 5 (25.0) | 1 (16.7) |
NEC necrotizing enterocolitis.
*Grade 1–4.
** ≤ 50 000 platelets per microlite.
+First 10 days after birth.
++Hemoglobin < 11 g/dl.
+++Grade I–IV.