Table 1.

Query terms used for the literature search in PubMed/MEDLINE.

Query term*	Article count
(Q1 AND Q2) NOT Q3	4,775
(Alzheimer*[tiab]) AND Q2) NOT Q3	2,514
(Multiple sclerosis[tiab] AND Q2) NOT Q3	570
(Parkinson*[tiab] AND Q2) NOT Q3	459
((Lou Gehrig* disease[tiab] OR amyotrophic lateral sclerosis[tiab]) AND Q2) NOT Q3	132
(Huntington*[tiab] AND Q2) NOT Q3	116

*Query term 1 (Q1): ((Pick’s disease[tiab] OR progressive supranuclear palsy[tiab] OR tauopathy[tiab] OR tauopathies[tiab] OR neuronal ceroid lipofuscinosis[tiab] OR hereditary spastic paraplegia[tiab] OR ataxia telangiectasia[tiab] OR creutzfeldt-jacob[tiab] OR prion disease[tiab] OR frontotemporal dementia[tiab] OR fronto-temporal dementia[tiab] OR polyglutamine disease[tiab] OR spinocerebellar ataxia*[tiab] OR spino-cerebellar ataxia*[tiab] OR motor neurone disease[tiab] OR motor neuron disease[tiab] OR motoneuron disease[tiab] OR Lou Gehrig* disease[tiab] OR amyotrophic lateral sclerosis[tiab] OR huntington*[tiab] OR parkinson*[tiab] OR alzheimer*[tiab] OR neurodegenerative[tiab] OR neurodegeneration[tiab] OR spinal muscular atrophy[tiab] OR multiple system atrophy[tiab] OR multiple sclerosis[tiab] OR dementia[tiab]). Query term 2 (Q2): (sterol OR cholesterol OR hydroxycholesterol OR hydroxy-cholesterol OR oxysterol). Query term 3 (Q3): (review OR niemann-pick disease type c2[tiab] OR niemann-pick type c2[tiab] OR niemann-pick disease type c1[tiab] OR niemann-pick type c1[tiab] OR niemann-pick type c[tiab] OR niemann-pick disease type c[tiab]).