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. 2021 Nov 16;11:22331. doi: 10.1038/s41598-021-01664-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Poised promoters are associated with neuronal genes while active promoters tend to mark housekeeping genes. (a) Genes associated with poised promoters are enriched for biological processes related to neuron development. (b) Genes associated with the PP state are enriched for genes with brain-specific expression (cortex, e14.5 brain, cerebellum, and olfactory bulb). (c) Genes associated with active promoters are enriched for biological processes related to general cellular functionality. (d) Genes associated with the AP state do not have tissue-specific gene expression, potentially indicating they are house-keeping genes. (e) Non-housekeeping AP state genes are enriched for genes involved in the cell cycle process. (f) Non-housekeeping AP state are enriched for genes with placenta-specific expression.