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. 2021 Nov 16;11:22331. doi: 10.1038/s41598-021-01664-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Transcription factors enriched in active enhancers. (a) Protein–protein interaction network comprised of TFs enriched within AE state intergenic or intronic regions. The darker the color, the higher the number of connections (edges). Light green outline indicates a gene with placenta-specific expression as defined by TissueEnrich. (b) The MYC TF targets genes are associated with embryonic lethality and prenatal size. (c) The JUN TF targets genes are associated with embryonic lethality and size. (d) The GATA4 TF targets genes associated with embryonic size, embryonic lethality, and cell morphology. (e) TissueEnrich heatmap showing the genes that have placenta-specific gene expression patterns. (f) The BHLHA15 TF targets genes associated with placental morphology.