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. 2021 Nov 16;12:6618. doi: 10.1038/s41467-021-26783-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Workflow of the meta-GWAS on rare variants in eczema is shown. Analyzing only rare/low-frequency variants, 11 loci were detected. In the complete data set, 38 loci were detected of which 6 were not reported to be associated with eczema or allergic disease previously. The significance threshold for the gene-level association analysis corresponds to 13,000 genes under study (carrying at least two variants with MAF < 0.05 and a CADD score ≥ 12.37). SNP single nucleotide polymorphism, MAF minor allele frequency.