Figure 5.

The number of pneumococcal colonies detected in various organs. The spleen (A), heart (B), lung (C), and brain (D) were collected on day 3 from the mice in the mono-infection and coinfection models. The data of the coinfection model were displayed. Each sample was thoroughly washed and homogenized in 1 ml of sterile PBS. Each symbol represents individual data. Eight of TRPV1 KO, 12 of TRPV4 KO, and 7 of wild-type mice were used. Horizontal lines indicate median values. The detection limit (the dotted line) is 666 CFU/ml. *p < 0.05 and **p < 0.01.