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. Author manuscript; available in PMC: 2023 Jan 1.
Published in final edited form as: J Cyst Fibros. 2021 May 17;21(1):172–180. doi: 10.1016/j.jcf.2021.04.010

Fig 2. Predicted alteration to upstream regulators and paracrine signaling in CF pancreatic ductal epithelia.

Fig 2.

(A) Volcano plot showing cAMP-stimulated differentially secreted proteins (DSPs) from the apical or basolateral surface of WT (N=4 donors) and CF (N=4 donors) pancreatic duct epithelia. Proteins labelled in the plot have a Log2FC>5 (p<0.5) or Log2FC<−5 (p<0.05). (B) Heatmap of predicted upstream regulators of the differential secretomes from the basolateral (Baso) and apical surface (p<0.05) of CF and WT pancreatic duct epithelium. The activation Z-score for each of the upstream regulators are shown in the heatmap to the right. (C) Chordplot showing putative functional interaction between the DSPs from the CF duct epithelium with exocrine, endocrine, and stromal cell types of the pancreas.