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. 2021 Nov 3;12:697725. doi: 10.3389/fimmu.2021.697725

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Copyright © 2021 Fu, Wang, Yu, Lin, Huang, Liu, Zhao, Lu, Xu, Liu, Liu, Wang and Chu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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IgA in DSS-induced colitis. (A) Iga^−/− mice and WT mice were administered DSS or regular water (water). Mice were evaluated daily, and weight loss and disease activity index (DAI) scores (B) were recorded. (C) Representative distal colon histological sections of Iga^−/− mice were stained with hematoxylin and eosin (H&E), and the histological score was calculated. Images are presented at the original magnification of ×100. Red stars indicate the position of the inflammatory cell infiltration and/or epithelial damage. (D) The colony-forming units (CFU) counts of the bacteria in the feces of WT mice or Iga^-/- mice on day 7 of colitis. (E) The O.D. values which indicated bacteria captured by the serum antibodies of WT mice or the Iga^-/- mice on day 7 after DSS intervention were measured. **P < 0.01, ***P < 0.001. Data are expressed as mean ± SEM of three mice.