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. 2021 Nov 3;12:758981. doi: 10.3389/fgene.2021.758981

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Copyright © 2021 Xu, Xie, Mao, Huang, Mei, Song, Sun, Yao and Shi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Prognostic significance of the ferroptosis-related gene signature derived risk scores in TGGA cohort. (A) Kaplan-Meier analysis of melanoma patients was stratified by median risk score in TCGA cohort. (B) Receiver operating characteristic (ROC) curve of risk score signature. (C, D) Kaplan-Meier analysis of melanoma patients was stratified by median risk score in GSE78220 cohort (C) and MSKCC cohort (D). (E, F) Univariate and multivariate Cox regression analysis showed the predictive utility of the risk-score signature possesses excellent prognostic independence. (G) The curve shows the distribution of patient risk scores, survival status, and survival time. (H) Heatmap shows the expression of each gene in the risk-score signature.