FIG. 1.

Structures and comparison of the hNRC and rNRC.1 isoforms. The upper section shows a schematic representation of the functional domains identified in hNRC and rNRC.1, a rat homologue, isolated from the GH4C1 pJG4-5 cDNA library. rNRC.1 is homologous to amino acids 771 to 1046 of hNRC. AD1 and AD2 are two activation domain regions, Q and P represent a glutamine- and proline-rich stretch of amino acids. LXXLL-1 is a nuclear receptor interaction motif. S-T-L is a serine-, threonine-, and leucine-rich sequence in the C-terminal part of hNRC which may be part of regulatory domain. LXXLL-2 is a second LXXLL motif which plays a less important role in nuclear receptor interactions. The lower section shows the amino acid sequence of rNRC.1 and its alignment with the corresponding region in hNRC. LXXLL-1 is underlined. The sequence of KIAA0181 is in GenBank under accession number D80003. We have extended the N terminus of hNRC and have deposited the sequence containing 58 additional amino acids in GenBank (accession number AF245115). The sequence of rNRC.1 has also been deposited in GenBank (accession number AF228043).