Table 1.
Descriptive statistics and associations between TILs and either pCR or RCB class per pathologist.
| Rater | TILs versus pCR p-value |
TILs versus RCB class p-value |
Mean TILs |
Min TILs |
Max TILs |
Range TILs |
Pe25 TILs |
Pe50 TILs |
Pe75 TILs |
|---|---|---|---|---|---|---|---|---|---|
| P01 | 0.020* | 0.073 | 23 | 0 | 80 | 80 | 5 | 20 | 35 |
| P02 | 0.003* | 0.031 | 22 | 0 | 77 | 77 | 5 | 10 | 40 |
| P03 | 0.001* | 0.004* | 24 | 2 | 90 | 88 | 5.5 | 10 | 42.5 |
| P04 | 0.001* | 0.004* | 42 | 5 | 100 | 95 | 20 | 40 | 70 |
| P05 | 0.101 | 0.394 | 36 | 2 | 90 | 88 | 7.5 | 30 | 60 |
| P06 | 0.002* | 0.011 | 35 | 5 | 80 | 75 | 10 | 30 | 55 |
| P07 | 0.003* | 0.019 | 43 | 5 | 90 | 85 | 17.5 | 40 | 70 |
| P08 | 0.003* | 0.006* | 17 | 0 | 80 | 80 | 2 | 10 | 20 |
| P09 | 0.001* | 0.007* | 29 | 2 | 80 | 78 | 15 | 20 | 40 |
| P10 | 0.004* | 0.021 | 20 | 1 | 80 | 79 | 5 | 10 | 30 |
| P11 | 0.014* | 0.083 | 31 | 1 | 80 | 79 | 5 | 20 | 30 |
| P12 | 0.004* | 0.021 | 29 | 5 | 90 | 85 | 8 | 15 | 50 |
| P13 | 0.007* | 0.020 | 31 | 1 | 90 | 89 | 10 | 30 | 40 |
| P14 | 0.002* | 0.011 | 17 | 0 | 90 | 90 | 0 | 5 | 40 |
| P15 | 0.011* | 0.045 | 30 | 3 | 80 | 77 | 8 | 18 | 55 |
| P16 | 0.003* | 0.021 | 44 | 5 | 100 | 95 | 20 | 40 | 75 |
| P17 | 0.005* | 0.034 | 38 | 1 | 90 | 89 | 10 | 30 | 65 |
| P18 | 0.120 | 0.333 | 25 | 4 | 80 | 76 | 15 | 25 | 62.5 |
| P19 | 0.019* | 0.081 | 27 | 0 | 90 | 90 | 50 | 10 | 45 |
| P20 | 0.009* | 0.041 | 25 | 1 | 80 | 79 | 5 | 20 | 45 |
| P21 | 0.024* | 0.054 | 26 | 2 | 90 | 88 | 5 | 10 | 30 |
| P22 | 0.002* | 0.018 | 26 | 2 | 90 | 88 | 12.5 | 25 | 55 |
| P23 | 0.013* | 0.016 | 20 | 1 | 70 | 69 | 5 | 17.5 | 40 |
| P24 | 0.001* | 0.009 | 31 | 5 | 90 | 85 | 10 | 20 | 70 |
| P25 | 0.006* | 0.030 | 31 | 2 | 90 | 88 | 10 | 40 | 70 |
| P26 | 0.016* | 0.036 | 25 | 0 | 80 | 80 | 5 | 10 | 35 |
| P27 | 0.006* | 0.044 | 29 | 5 | 80 | 75 | 5 | 30 | 70 |
| P28 | 0.014* | 0.092 | 38 | 1 | 95 | 94 | 1 | 10 | 80 |
| P29 | 0.004* | 0.018 | 29 | 2 | 95 | 93 | 10 | 30 | 55 |
| P30 | 0.001* | 0.008* | 23 | 2 | 90 | 88 | 7.5 | 15 | 30 |
| P31 | 0.013$ | 0.055 | 30 | 1 | 90 | 89 | 20 | 30 | 75 |
| P32 | 0.002* | 0.006* | 27 | 0 | 90 | 90 | 10 | 30 | 60 |
| P33 | 0.024* | 0.049 | 25 | 0 | 80 | 80 | 5 | 20 | 40 |
| P34 | 0.002* | 0.007* | 30 | 1 | 90 | 89 | 7.5 | 20 | 60 |
| P35 | 0.159 | 0.561 | 28 | 1 | 90 | 89 | 5 | 10 | 35 |
| P36 | 0.005* | 0.009 | 20 | 5 | 75 | 70 | 10 | 30 | 50 |
| P37 | 0.003* | 0.009 | 32 | 3 | 100 | 97 | 10 | 40 | 75 |
| P38 | 0.014* | 0.075 | 35 | 10 | 80 | 70 | 20 | 30 | 50 |
| P39 | 0.002* | 0.007* | 38 | 0 | 100 | 100 | 5 | 10 | 35 |
| P40 | 0.001* | 0.009 | 34 | 1 | 90 | 89 | 7.5 | 20 | 70 |
| Px | 0.004* | 0.020 | 29 | 5 | 80 | 75 | 9.5 | 20 | 50 |
*
Statistically significant association, with the significance level set at 0.05 (for TILs versus pCR, Mann-Whitney U test) or 0.0083 (for TILs versus RCB class, Kruskal-Wallis test with post hoc Bonferroni correction).
$
Inverse statistically significant association, i.e. pCR was associated with lower TILs levels.
Max: maximum TILs value; Min: minimum TILs value; Pe25: 25th percentile; Pe50: 50th percentile or median; Pe75: 75th percentile; pCR: pathological complete response; Range: difference between maximum and minimum TILs; TILs: tumor-infiltrating lymphocytes