Table 3.
DEGs between young male and female lens fiber cells. Bold denotes genes that have been previously reported to exhibit sex dependent expression in adult mouse tissues based on comparisons with SAGD (Shi et al., 2019). Italics denotes genes that exhibit lens preferred expression in postnatal day 56 mouse lenses according to the iSyTe database (Kakrana et al., 2018).
| SYMBOL | DESCRIPTION | Chromosome | Fold Change | FDR | Male FPKM | Female FPKM |
|---|---|---|---|---|---|---|
| Xist | inactive X specific transcripts | X | 312.7 | 9.72E-48 | 0.0 | 10.1 |
| Adrb2 | adrenergic receptor, beta 2 | 18 | 173.0 | 7.14E-3 | 0.0 | 2.3 |
| Mrpl22 | mitochondrial ribosomal protein L22 | 11 | 16.5 | 9.66E-3 | 0.2 | 4.1 |
| Tm7sf3 | transmembrane 7 superfamily member 3 | 6 | 13.1 | 3.63E-8 | 0.3 | 4.3 |
| Selenon | selenoprotein N | 4 | 6.3 | 8.76E-7 | 0.7 | 4.3 |
| Gm10557 | predicted gene 10557 | 18 | 5.9 | 6.90E-3 | 1.9 | 11.8 |
| Sdhc | succinate dehydrogenase complex, subunit C | 1 | 5.8 | 5.00E-4 | 0.6 | 3.6 |
| Mfsd1 | major facilitator superfamily domain containing 1 | 3 | 5.7 | 5.01E-3 | 0.5 | 2.9 |
| Olfml3 | olfactomedin-like 3 | 3 | 5.0 | 1.31E-5 | 0.7 | 3.3 |
| Ppp3cc | protein phosphatase 3, catalytic subunit, gamma isoform | 14 | 4.7 | 4.52E-2 | 0.6 | 2.7 |
| Rab39b | RAB39B, member RAS oncogene family | X | 4.1 | 2.43E-2 | 0.8 | 3.4 |
| Rassf7 | Ras association (RalGDS/AF-6) domain family (N-terminal) 7 | 7 | 3.8 | 3.79E-2 | 1.2 | 4.8 |
| Samd1 | sterile alpha motif domain containing 1 | 8 | 3.7 | 1.70E-3 | 1.6 | 5.9 |
| Ahcy | S-adenosylhomocysteine hydrolase | 2 | 3.5 | 1.14E-2 | 2.4 | 8.4 |
| Armc10 | armadillo repeat containing 10 | 5 | 3.3 | 2.62E-2 | 1.2 | 3.9 |
| Bnip2 | BCL2/adenovirus E1B interacting protein 2 | 9 | 2.8 | 2.48E-2 | 1.3 | 3.6 |
| Aldh3a1 | aldehyde dehydrogenase family 3, subfamily A1 | 11 | 2.8 | 7.19E-4 | 5.5 | 15.6 |
| Mapkapk2 | MAP kinase-activated protein kinase 2 | 1 | 2.7 | 2.01E-2 | 1.2 | 3.4 |
| Rbm7 | RNA binding motif protein 7 | 9 | 2.6 | 2.35E-2 | 1.4 | 3.6 |
| Ptpn2 | protein tyrosine phosphatase, non-receptor type 2 | 18 | 2.6 | 2.69E-2 | 2.6 | 6.5 |
| Epg5 | ectopic P-granules autophagy protein 5 homolog (C. elegans) | 18 | 2.5 | 1.29E-3 | 1.4 | 3.5 |
| Retreg1 | reticulophagy regulator 1 | 15 | 2.5 | 5.94E-3 | 2.4 | 6.0 |
| Flcn | folliculin | 11 | 2.3 | 2.62E-2 | 1.8 | 4.2 |
| Acat1 | acetyl-Coenzyme A acetyltransferase 1 | 9 | 2.3 | 4.15E-2 | 2.3 | 5.4 |
| Gstm1 | glutathione S-transferase, mu 1 | 3 | 2.3 | 6.70E-4 | 15.1 | 34.7 |
| 2410004B18Rik | RIKEN cDNA 2410004B18 gene | 3 | 2.2 | 6.39E-3 | 8.1 | 18.2 |
| Zc3h4 | zinc finger CCCH-type containing 4 | 7 | 2.1 | 5.86E-4 | 2.3 | 4.9 |
| Exoc3 | exocyst complex component 3 | 13 | 2.0 | 1.14E-2 | 3.7 | 7.5 |
| Arpc5 | actin related protein 2/3 complex, subunit 5 | 1 | −2.0 | 3.02E-2 | 15.3 | 7.6 |
| Hmgb3 | high mobility group box 3 | X | −2.1 | 5.94E-3 | 25.3 | 12.3 |
| Cxxc1 | CXXC finger 1 (PHD domain) | 18 | −2.1 | 1.81E-2 | 8.4 | 4.0 |
| Mtmr4 | myotubularin related protein 4 | 11 | −2.2 | 3.79E-2 | 5.3 | 2.4 |
| Arhgef19 | Rho guanine nucleotide exchange factor (GEF) 19 | 4 | −2.2 | 2.46E-2 | 3.7 | 1.7 |
| Ahdc1 | AT hook, DNA binding motif, containing 1 | 4 | −2.3 | 5.53E-4 | 4.1 | 1.8 |
| Oplah | 5-oxoprolinase (ATP-hydrolysing) | 15 | −2.3 | 1.14E-2 | 3.8 | 1.7 |
| Tm9sf1 | transmembrane 9 superfamily member 1 | 14 | −2.7 | 1.79E-2 | 3.5 | 1.3 |
| Zdhhc4 | zinc finger, DHHC domain containing 4 | 5 | −2.7 | 3.85E-2 | 7.1 | 2.6 |
| Susd4 | sushi domain containing 4 | 1 | −2.9 | 2.83E-2 | 5.0 | 1.7 |
| Spsb3 | splA/ryanodine receptor domain and SOCS box containing 3 | 17 | −2.9 | 4.52E-2 | 6.3 | 2.1 |
| Pygm | muscle glycogen phosphorylase | 19 | −3.1 | 7.34E-3 | 4.6 | 1.5 |
| Gm14322 | predicted gene 14322 | 2 | −3.2 | 3.71E-2 | 13.3 | 4.1 |
| Map2k1 | mitogen-activated protein kinase kinase 1 | 9 | −3.3 | 1.15E-4 | 6.2 | 1.9 |
| Cntfr | ciliary neurotrophic factor receptor | 4 | −3.8 | 4.15E-2 | 3.2 | 0.8 |
| Yipf2 | Yip1 domain family, member 2 | 9 | −6.4 | 5.09E-3 | 4.6 | 0.7 |
| S100a1 | S100 calcium binding protein A1 | 3 | −17.3 | 1.02E-2 | 6.7 | 0.3 |
| Tmub1 | transmembrane and ubiquitin-like domain containing 1 | 5 | −18.5 | 1.04E-3 | 2.6 | 0.1 |
| A930036I15Rik | RIKEN cDNA A930036I15 gene | 3 | −81.7 | 3.91E-2 | 2.2 | 0.0 |
| Ddx3y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | Y | −335.4 | 1.68E-43 | 9.6 | 0.0 |
| Eif2s3y | eukaryotic translation initiation factor 2, subunit 3, Y-linked | Y | −570.3 | 7.04E-11 | 3.9 | 0.0 |