Table 4.
DEGs between aged male and female lens epithelial cells. Bold denotes genes that have been previously reported to exhibit sex dependent expression in adult mouse tissues based on comparisons with SAGD (Shi et al., 2019). Italics denotes genes that exhibit lens preferred expression in postnatal day 56 mouse lenses according to the iSyTe database (Kakrana et al., 2018).
| SYMBOL | DESCRIPTION | Chromosome | Fold Change | FDR | Male FPKM | Female FPKM |
|---|---|---|---|---|---|---|
| Xist | inactive X specific transcripts | X | 1932.6 | 3.61E-92 | 0.0 | 34.6 |
| Crygd | crystallin, gamma D | 1 | 60.3 | 2.36E-2 | 0.0 | 2.8 |
| Gm49958 | predicted gene, 49958 | 17 | 7.9 | 6.62E-5 | 0.3 | 2.5 |
| Rgs4 | regulator of G-protein signaling 4 | 1 | 5.2 | 1.29E-2 | 0.6 | 3.3 |
| Lgsn | lengsin, lens protein with glutamine synthetase domain | 1 | 4.5 | 4.79E-3 | 19.9 | 88.6 |
| Pip5kl1 | phosphatidylinositol-4-phosphate 5-kinase-like 1 | 2 | 3.6 | 1.18E-3 | 1.1 | 3.8 |
| Gm42808 | predicted gene 42808 | 5 | 3.5 | 5.55E-3 | 10.6 | 36.9 |
| Fabp5 | fatty acid binding protein 5, epidermal | 3 | 3.3 | 1.18E-2 | 14.8 | 48.1 |
| Acta2 | actin, alpha 2, smooth muscle, aorta | 19 | 3.3 | 4.76E-9 | 10.8 | 35.1 |
| Cryba4 | crystallin, beta A4 | 5 | 3.2 | 5.90E-3 | 179.0 | 581.3 |
| Rny1 | RNA, Y1 small cytoplasmic, Ro-associated | 6 | 3.2 | 3.16E-2 | 10.8 | 34.7 |
| Pstpip2 | proline-serine-threonine phosphatase-interacting protein 2 | 18 | 2.8 | 1.11E-3 | 1.3 | 3.8 |
| Mboat1 | membrane bound O-acyltransferase domain containing 1 | 13 | 2.8 | 2.73E-9 | 3.2 | 8.9 |
| Crybb1 | crystallin, beta B1 | 5 | 2.4 | 1.50E-2 | 173.1 | 407.3 |
| Cryba1 | crystallin, beta A1 | 11 | 2.3 | 8.08E-3 | 356.8 | 830.6 |
| Crygs | crystallin, gamma S | 16 | 2.3 | 8.58E-3 | 567.8 | 1321.6 |
| Lctl | lactase-like | 9 | 2.3 | 2.66E-2 | 7.5 | 17.0 |
| Smco3 | single-pass membrane protein with coiled-coil domains 3 | 6 | 2.3 | 5.34E-4 | 2.4 | 5.4 |
| Basp1 | brain abundant, membrane attached signal protein 1 | 15 | 2.2 | 8.58E-3 | 39.9 | 87.0 |
| Snhg12 | small nucleolar RNA host gene 12 | 4 | 2.2 | 1.06E-2 | 1.8 | 3.9 |
| Dpf3 | D4, zinc and double PHD fingers, family 3 | 12 | 2.2 | 8.58E-3 | 1.9 | 4.1 |
| Tmem40 | transmembrane protein 40 | 6 | 2.1 | 8.96E-3 | 5.0 | 10.6 |
| Arhgap31 | Rho GTPase activating protein 31 | 16 | 2.1 | 5.34E-4 | 2.1 | 4.4 |
| Cryba2 | crystallin, beta A2 | 1 | 2.1 | 4.99E-3 | 661.3 | 1371.1 |
| Efemp1 | epidermal growth factor-containing fibulin-like extracellular matrix protein 1 | 11 | −2.0 | 2.36E-2 | 33.6 | 16.7 |
| Slc6a6 | solute carrier family 6 (neurotransmitter transporter, taurine), member 6 | 6 | −2.0 | 1.83E-4 | 128.6 | 62.7 |
| Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 13 | −2.3 | 9.69E-3 | 4.6 | 2.0 |
| F5 | coagulation factor V | 1 | −2.3 | 9.80E-3 | 15.2 | 6.5 |
| Gpx3 | glutathione peroxidase 3 | 11 | −2.4 | 9.69E-5 | 229.3 | 97.4 |
| Matn2 | matrilin 2 | 15 | −2.6 | 3.26E-2 | 5.7 | 2.2 |
| Plin4 | perilipin 4 | 17 | −3.2 | 1.76E-2 | 3.7 | 1.2 |
| Col9a1 | collagen, type IX, alpha 1 | 1 | −3.5 | 2.00E-6 | 11.9 | 3.4 |
| Crhbp | corticotropin releasing hormone binding protein | 13 | −3.5 | 1.18E-3 | 21.4 | 6.2 |
| Fbn1 | fibrillin 1 | 2 | −3.7 | 3.58E-10 | 32.3 | 8.6 |
| Krt12 | keratin 12 | 11 | −27.8 | 1.18E-3 | 3.5 | 0.1 |
| Eif2s3y | eukaryotic translation initiation factor 2, subunit 3, Y-linked | Y | −592.9 | 5.01E-21 | 2.6 | 0.0 |
| Ddx3y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | Y | −856.2 | 5.65E-93 | 7.8 | 0.0 |