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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Exp Eye Res. 2021 Jun 17;209:108676. doi: 10.1016/j.exer.2021.108676

Table 6.

DEGs between aged male and female lens epithelial cells at 24 hours PCS Bold denotes genes that have been previously reported to exhibit sex dependent expression in adult mouse tissues based on comparisons with SAGD (Shi et al., 2019).. Italics denotes genes that exhibit lens preferred expression in postnatal day 56 mouse lenses according to the iSyTe database (Kakrana et al., 2018).

SYMBOL DESCRIPTION Chromosome Fold Change FDR Male FPKM Female FPKM
Endog endonuclease G 2 400.3 1.52E-5 0.0 2.7
A730094K22Rik RIKEN cDNA A730094K22 gene 9 361.3 2.06E-4 0.0 3.5
Gm24644 predicted gene, 24644 2 337.4 8.11E-4 0.0 17.5
Gm18840 predicted gene, 18840 6 264.2 2.65E-2 0.0 3.7
Xist inactive X specific transcripts X 107.5 1.47E-2 0.5 54.8
Lipt2 lipoyl(octanoyl) transferase 2 (putative) 7 21.3 2.66E-4 0.1 2.5
Rpl17-ps8 ribosomal protein L17, pseudogene 8 X 13.8 3.63E-3 0.4 5.6
Steap4 STEAP family member 4 5 13.8 3.13E-2 2.3 31.4
Efemp1 epidermal growth factor-containing fibulin-like extracellular matrix protein 1 11 13.4 1.35E-8 4.2 57.2
Foxi3 forkhead box I3 6 12.1 2.48E-3 0.4 4.4
Kcnj13 potassium inwardly-rectifying channel, subfamily J, member 13 1 12.1 9.93E-3 0.3 3.8
Lgi2 leucine-rich repeat LGI family, member 2 5 11.3 5.49E-4 0.5 5.5
Myl6b myosin, light polypeptide 6B] 10 11.1 4.34E-3 0.3 3.0
C1ra complement component 1, r subcomponent A 6 10.8 2.99E-5 0.6 6.5
Slc6a13 solute carrier family 6 (neurotransmitter transporter, GABA), member 13 6 10.4 3.98E-4 0.6 6.8
Rida reactive intermediate imine deaminase A homolog 15 10.3 1.71E-3 0.3 3.5
Chil1 chitinase-like 1 1 9.9 2.76E-2 7.9 78.4
Dio3 deiodinase, iodothyronine type III 12 9.8 2.50E-2 1.0 10.1
Klhdc7a kelch domain containing 7A 4 9.6 2.10E-6 0.3 3.2
Npvf neuropeptide VF precursor 6 9.5 1.33E-2 1.3 12.2
Six6 sine oculis-related homeobox 6 12 9.5 2.33E-4 0.4 3.6
Tyrp1 tyrosinase-related protein 1 4 9.1 4.52E-4 0.4 4.1
Mfrp membrane frizzled-related protein 9 8.9 1.06E-3 0.5 4.6
A2m alpha-2-macroglobulin 6 8.8 3.65E-3 1.9 16.5
Bmp4 bone morphogenetic protein 4 14 8.7 1.52E-3 0.7 6.5
Chrm1 cholinergic receptor, muscarinic 1, CNS 19 8.7 2.39E-4 0.4 3.5
Slc7a4 solute carrier family 7 (cationic amino acid transporter, y+ system), member 4 16 8.6 5.18E-3 0.5 4.0
Sod3 superoxide dismutase 3, extracellular 5 8.5 4.27E-2 18.5 156.7
Slc16a2 solute carrier family 16 (monocarboxylic acid transporters), 2 X 8.5 1.25E-2 2.1 18.1
Rab3b RAB3B, member RAS oncogene family 4 7.8 2.41E-2 0.4 3.3
Rtl8c retrotransposon Gag like 8C X 7.8 1.67E-2 0.9 7.5
Macrod1 mono-ADP ribosylhydrolase 1 19 7.8 1.90E-2 0.3 2.3
Cdh11 cadherin 11 8 7.7 7.28E-4 0.3 2.5
Mme membrane metallo endopeptidase 3 7.5 3.56E-2 1.7 13.0
Prkcq protein kinase C, theta 2 7.4 5.13E-3 0.5 4.0
Wfdc1 WAP four-disulfide core domain 1 8 7.2 4.73E-3 0.8 5.9
Otx1 orthodenticle homeobox 1 11 7.0 4.85E-2 0.5 3.4
Sord sorbitol dehydrogenase 2 7.0 1.49E-2 1.0 6.8
Cldn2 claudin 2 X 6.9 6.83E-4 0.6 4.1
Ajap1 adherens junction associated protein 1 4 6.4 1.14E-2 0.4 2.8
Cavin2 caveolae associated 2 1 6.4 9.88E-3 2.8 17.8
Map3k21 mitogen-activated protein kinase kinase kinase 21 8 6.4 7.27E-3 0.6 3.9
Zmat5 zinc finger, matrin type 5 11 6.3 1.33E-2 0.6 3.6
Rab3il1 RAB3A interacting protein (rabin3)-like 1 19 6.3 2.11E-2 0.4 2.5
Zic1 zinc finger protein of the cerebellum 1 9 6.2 2.35E-3 1.2 7.2
Gm14322 predicted gene 14322 2 6.2 9.97E-3 0.5 3.2
Ephb2 Eph receptor B2 4 6.1 2.02E-5 0.4 2.4
Selenop selenoprotein P 15 6.0 2.10E-2 1.6 9.9
Pdgfra platelet derived growth factor receptor, alpha polypeptide 5 6.0 4.97E-2 0.4 2.5
Slc13a4 solute carrier family 13 (sodium/sulfate symporters), member 4 6 5.8 9.49E-4 1.5 8.9
Apcdd1 adenomatosis polyposis coli down-regulated 1 18 5.8 9.60E-4 0.5 2.8
Serping1 serine (or cysteine) peptidase inhibitor, clade G, member 1 2 5.7 1.13E-12 4.8 27.6
Aass aminoadipate-semialdehyde synthase 6 5.6 1.62E-2 0.5 2.9
Mrgprf MAS-related GPR, member F 7 5.6 1.64E-2 0.5 2.9
Zic2 zinc finger protein of the cerebellum 2 14 5.6 2.19E-4 1.9 10.7
Mab21l2 mab-21-like 2 3 5.5 6.22E-6 1.9 10.6
Lrp2 low density lipoprotein receptor-related protein 2 2 5.5 6.15E-4 1.0 5.3
Nr2f1 nuclear receptor subfamily 2, group F, member 1 13 5.4 3.42E-2 0.9 5.1
Cp ceruloplasmin 3 5.4 3.08E-6 21.7 117.4
Tmem176b transmembrane protein 176B 6 5.4 1.24E-7 7.0 37.9
Adamts5 a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 5 (aggrecanase-2) 16 5.3 5.58E-10 1.2 6.2
C1qb complement component 1, q subcomponent, beta polypeptide 4 5.3 9.88E-3 1.5 8.3
Gm14325 predicted gene 14325 2 5.1 2.51E-2 0.8 4.4
Lsr lipolysis stimulated lipoprotein receptor 7 5.1 4.12E-2 0.8 4.0
F5 coagulation factor V 1 5.0 4.02E-5 2.8 14.3
Bcam basal cell adhesion molecule 7 5.0 1.27E-4 1.4 7.2
Nid2 nidogen 2 14 4.8 1.20E-2 1.9 9.1
Snapc5 small nuclear RNA activating complex, polypeptide 5 9 4.8 2.02E-2 0.9 4.4
Rhoj ras homolog family member J 12 4.6 1.12E-2 2.7 12.4
Reln reelin 5 4.6 2.88E-6 4.0 18.6
Fmod fibromodulin 1 4.6 1.89E-5 3.7 17.0
Colgalt2 collagen beta(1-O)galactosyltransferase 2 1 4.6 3.08E-6 1.1 5.1
Pcyt1b phosphate cytidylyltransferase 1, choline, beta isoform X 4.6 2.41E-3 1.9 8.6
Olfml2a olfactomedin-like 2A 2 4.6 2.62E-7 4.7 21.7
Vat1l vesicle amine transport protein 1 like 8 4.6 3.45E-4 1.0 4.7
Hopx HOP homeobox 5 4.6 6.42E-3 1.4 6.6
S1pr3 sphingosine-1-phosphate receptor 3 13 4.5 4.38E-9 6.6 29.6
Jam2 junction adhesion molecule 2 16 4.3 1.65E-2 1.6 6.8
Tmem176a transmembrane protein 176 A 6 4.3 2.79E-4 2.6 11.4
Aqp4 aquaporin 4 18 4.3 8.57E-8 3.2 13.7
Rtn4rl1 reticulon 4 receptor-like 1 11 4.3 1.26E-3 1.9 8.2
Gpm6a glycoprotein m6a 8 4.3 8.36E-4 2.0 8.6
Il1r1 interleukin 1 receptor, type I 1 4.3 3.56E-2 1.2 5.2
Enpp5 ectonucleotide pyrophosphatase/phosphodiesterase 5 17 4.2 1.89E-3 1.4 6.1
Trp53i11 transformation related protein 53 inducible protein 11 2 4.2 2.72E-3 1.0 4.3
Sema3d sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D 5 4.2 2.67E-2 1.4 5.7
Fbn1 fibrillin 1 2 4.2 2.04E-3 8.1 33.8
C1s1 complement component 1, s subcomponent 1 6 4.2 2.43E-2 1.3 5.3
Mturn maturin, neural progenitor differentiation regulator homolog 6 4.1 2.20E-2 1.9 7.8
Ogn osteoglycin 13 4.1 2.92E-2 3.7 15.2
Klf15 Kruppel-like factor 15 6 4.1 1.74E-2 0.9 3.6
Rarres2 retinoic acid receptor responder (tazarotene induced) 2 6 4.1 4.42E-4 1.4 5.6
Napepld N-acyl phosphatidylethanolamine phospholipase D 5 4.0 4.10E-2 1.4 5.4
Cdh4 cadherin 4 2 4.0 9.60E-4 1.5 6.0
Lrrc75b leucine rich repeat containing 75B 10 4.0 1.90E-2 1.0 3.9
Lypd6 LY 6/PLAUR domain containing 6 2 4.0 4.40E-2 1.2 4.7
Flrt1 fibronectin leucine rich transmembrane protein 1 19 4.0 8.28E-5 1.5 5.8
Pcx pyruvate carboxylase 19 3.9 4.63E-5 1.0 4.0
Gpx3 glutathione peroxidase 3 11 3.9 3.04E-3 58.8 230.7
Zfp982 zinc finger protein 982 4 3.9 1.02E-2 1.2 4.6
Col18a1 collagen, type XVIII, alpha 1 10 3.9 3.32E-2 23.3 91.0
Serpinb9 serine (or cysteine) peptidase inhibitor, clade B, member 9 13 3.9 4.39E-2 0.8 3.3
C4b complement component 4B (Chido blood group) 17 3.8 2.46E-4 3.7 14.3
Amph amphiphysin 13 3.8 1.50E-5 5.3 20.2
Mrc2 mannose receptor, C type 2 11 3.8 2.70E-2 1.2 4.6
Alad aminolevulinate, delta-, dehydratase 4 3.8 3.07E-2 7.3 27.7
Col1a2 collagen, type I, alpha 2 6 3.8 9.39E-3 0.9 3.5
Prelp proline arginine-rich end leucine-rich repeat 1 3.8 2.63E-3 5.2 19.8
Optc opticin 1 3.8 7.73E-5 21.5 81.0
Otulinl OTU deubiquitinase with linear linkage specificity like 15 3.7 4.30E-2 0.8 3.0
Sorcs1 sortilin-related VPS10 domain containing receptor 1 19 3.7 2.34E-2 0.8 2.9
Ephx2 epoxide hydrolase 2, cytoplasmic 14 3.7 1.01E-3 3.0 10.9
Csad cysteine sulfinic acid decarboxylase 15 3.6 4.33E-2 3.9 13.9
Ntrk2 neurotrophic tyrosine kinase, receptor, type 2 13 3.6 6.51E-3 1.0 3.4
Fbln1 fibulin 1 15 3.5 3.09E-4 15.3 54.3
Smarcd3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3 5 3.5 2.97E-6 1.8 6.5
Mtus1 mitochondrial tumor suppressor 1 8 3.5 2.89E-4 2.0 7.0
Pla2g5 phospholipase A2, group V 4 3.5 1.71E-3 4.7 16.5
Copz2 coatomer protein complex, subunit zeta 2 11 3.5 2.54E-2 1.3 4.4
Abat 4-aminobutyrate aminotransferase 16 3.5 9.37E-3 2.1 7.3
Ipp IAP promoted placental gene 4 3.5 4.84E-2 0.8 2.9
Atp2b4 ATPase, Ca++ transporting, plasma membrane 4 1 3.5 2.18E-4 2.0 6.9
Fundc1 FUN14 domain containing 1 X 3.5 1.10E-2 3.0 10.4
Mgst1 microsomal glutathione S-transferase 1 6 3.4 9.57E-6 3.6 12.6
Ccn5 cellular communication network factor 5 2 3.4 1.23E-2 3.0 10.4
Hacd4 3-hydroxyacyl-CoA dehydratase 4 4 3.4 4.17E-2 1.0 3.3
Galnt12 polypeptide N-acetylgalactosaminyltransferase 12 4 3.4 3.17E-2 1.5 5.2
Boc biregional cell adhesion molecule-related/down-regulated by oncogenes (Cdon) binding protein 16 3.4 1.84E-3 1.6 5.4
Atp1a2 ATPase, Na+/K+ transporting, alpha 2 polypeptide 1 3.4 6.34E-3 29.1 99.1
Pafah2 platelet-activating factor acetylhydrolase 2 4 3.4 2.93E-3 1.2 4.2
Cdon cell adhesion molecule-related/down-regulated by oncogenes 9 3.4 2.66E-5 4.3 14.7
Crhbp corticotropin releasing hormone binding protein 13 3.4 4.54E-2 5.7 19.4
Lhx2 LIM homeobox protein 2 2 3.4 2.22E-2 1.6 5.3
Oplah 5-oxoprolinase (ATP-hydrolysing) 15 3.3 7.22E-4 1.5 4.9
St8sia1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1 6 3.3 5.52E-3 1.2 4.1
Fcgrt Fc receptor, IgG, alpha chain transporter 7 3.3 3.65E-3 2.3 7.5
Oat ornithine aminotransferase 7 3.3 1.15E-2 15.7 52.0
Vcan versican 13 3.3 7.61E-3 4.0 13.3
Pdk2 pyruvate dehydrogenase kinase, isoenzyme 2 11 3.3 9.84E-3 4.2 13.7
Col23a1 collagen, type XXIII, alpha 1 11 3.3 3.96E-2 8.1 26.7
Anapc13 anaphase promoting complex subunit 13 9 3.3 4.80E-2 2.3 7.5
Scx scleraxis 15 3.2 1.45E-3 1.9 6.2
Cyp39a1 cytochrome P450, family 39, subfamily a, polypeptide 1 17 3.2 1.19E-2 1.2 3.9
Pdcd4 programmed cell death 4 19 3.2 2.11E-2 17.1 54.7
Paxx non-homologous end joining factor 2 3.2 2.74E-2 2.0 6.3
Pcolce procollagen C-endopeptidase enhancer protein 5 3.2 5.69E-4 3.9 12.2
Ildr2 immunoglobulin-like domain containing receptor 2 1 3.2 6.81E-7 5.6 17.5
Gm7694 predicted gene 7694 1 3.2 3.27E-4 3.3 10.4
Mrpl34 mitochondrial ribosomal protein L34 8 3.2 4.23E-2 3.5 11.3
Jup junction plakoglobin 11 3.2 1.62E-3 1.5 4.6
Gas1 growth arrest specific 1 13 3.2 7.41E-6 7.6 24.0
9130023H24Rik RIKEN cDNA 9130023H24 gene 7 3.1 1.44E-2 1.0 3.1
Zfp185 zinc finger protein 185 X 3.1 4.76E-5 3.3 10.2
Oxct1 3-oxoacid CoA transferase 1 15 3.1 1.03E-4 3.1 9.5
Slc1a3 solute carrier family 1 (glial high affinity glutamate transporter), 3 15 3.1 5.18E-3 1.2 3.7
Prxl2a peroxiredoxin like 2A 14 3.1 7.30E-6 7.4 22.7
Rcan2 regulator of calcineurin 2 17 3.1 1.02E-2 3.3 10.2
Isyna1 myo-inositol 1-phosphate synthase A1 8 3.1 9.03E-3 6.2 19.0
Epm2a epilepsy, progressive myoclonic epilepsy, type 2 gene alpha 10 3.1 2.37E-2 1.0 3.2
Atp1b3 ATPase, Na+/K+ transporting, beta 3 polypeptide 9 3.0 2.43E-2 53.6 163.6
Pnmal2 PNMA-like 2 7 3.0 1.86E-2 5.5 16.6
Rorc RAR-related orphan receptor gamma 3 3.0 1.91E-2 1.7 5.1
Epas1 endothelial PAS domain protein 1 17 3.0 1.90E-2 5.5 16.6
Ndufb4 NADH:ubiquinone oxidoreductase subunit B4 16 3.0 8.21E-3 4.2 12.6
Ech1 enoyl coenzyme A hydratase 1, peroxisomal 7 3.0 7.41E-4 2.4 7.0
Ndrg1 N-myc downstream regulated gene 1 15 3.0 7.59E-3 8.0 23.7
Acadsb acyl-Coenzyme A dehydrogenase, short/branched chain 7 3.0 1.52E-3 2.4 7.1
Scara3 scavenger receptor class A, member 3 14 3.0 1.02E-2 1.5 4.4
Lix1l Lix1-like 3 3.0 1.34E-4 3.2 9.3
Abi3bp ABI gene family, member 3 (NESH) binding protein 16 2.9 3.12E-3 4.4 12.9
Stra6 stimulated by retinoic acid gene 6 9 2.9 2.66E-2 1.3 4.0
Sntb1 syntrophin, basic 1 15 2.9 9.84E-3 3.3 9.7
Ephb6 Eph receptor B6 6 2.9 7.79E-3 1.3 3.7
Loxl1 lysyl oxidase-like 1 9 2.9 2.29E-5 11.3 33.1
Fat4 FAT atypical cadherin 4 3 2.9 3.62E-3 6.1 17.9
Itgb8 integrin beta 8 12 2.9 2.06E-2 1.8 5.2
Sesn1 sestrin 1 10 2.9 1.94E-2 3.3 9.6
Irs1 insulin receptor substrate 1 1 2.9 3.46E-3 2.0 5.8
Gldc glycine decarboxylase 19 2.9 1.62E-3 5.0 14.3
Porcn porcupine O-acyltransferase X 2.9 1.12E-3 3.4 9.7
Gulp1 GULP, engulfment adaptor PTB domain containing 1 1 2.9 1.52E-2 1.3 3.8
Sqor sulfide quinone oxidoreductase 2 2.9 3.69E-3 1.1 3.1
Fbxo10 F-box protein 10 4 2.9 1.23E-3 1.4 4.1
Dll 1 delta like canonical Notch ligand 1 17 2.9 1.92E-2 2.4 6.7
Plaat3 phospholipase A and acyltransferase 3 19 2.9 3.56E-2 1.8 5.1
Ptgds prostaglandin D2 synthase (brain) 2 2.8 1.37E-3 116.1 329.2
Dync2li 1 dynein cytoplasmic 2 light intermediate chain 1 17 2.8 4.17E-2 1.5 4.2
Ndufa4 Ndufa4, mitochondrial complex associated 6 2.8 4.72E-2 2.2 6.2
Zhx1 zinc fingers and homeoboxes 1 15 2.8 1.95E-2 2.2 6.3
Alg14 asparagine-linked glycosylation 14 3 2.8 1.71E-2 1.3 3.6
Chchd10 coiled-coil-helix-coiled-coil-helix domain containing 10 10 2.8 4.27E-4 7.0 19.4
Fads2 fatty acid desaturase 2 19 2.8 2.70E-4 6.9 19.2
Surf1 surfeit gene 1 2 2.7 6.80E-3 3.3 9.1
Pdpr pyruvate dehydrogenase phosphatase regulatory subunit 8 2.7 5.96E-3 1.3 3.5
Rbms2 RNA binding motif, single stranded interacting protein 2 10 2.7 5.19E-3 1.7 4.7
Idh1 isocitrate dehydrogenase 1 (NADP+), soluble 1 2.7 3.60E-3 3.3 8.9
Rnf43 ring finger protein 43] 11 2.7 7.45E-3 1.3 3.6
Aldh6a1 aldehyde dehydrogenase family 6, subfamily A1 12 2.7 2.89E-2 1.6 4.2
Parm1 prostate androgen-regulated mucin-like protein 1 5 2.6 1.26E-2 3.4 9.1
Igfbp4 insulin-like growth factor binding protein 4 11 2.6 2.02E-2 6.9 18.2
Shisa2 shisa family member 2 14 2.6 4.95E-2 1.6 4.2
Fam107a family with sequence similarity 107, member A 14 2.6 2.76E-2 2.5 6.5
Hltf helicase-like transcription factor 3 2.6 5.11E-3 1.7 4.3
Gm44250 predicted gene, 44250 6 2.6 1.54E-2 1.3 3.3
Slc4a5 solute carrier family 4, sodium bicarbonate cotransporter, member 5 6 2.6 2.86E-2 3.0 7.7
Scp2 sterol carrier protein 2, liver [ 4 2.6 9.03E-3 9.4 24.1
Antxr1 anthrax toxin receptor 1 6 2.6 5.58E-3 5.3 13.5
Rdh10 retinol dehydrogenase 10 (all-trans) 1 2.5 1.03E-2 8.9 22.7
Slc22a17 solute carrier family 22 (organic cation transporter), member 17 14 2.5 1.06E-2 2.8 7.2
Apoe apolipoprotein E 7 2.5 1.18E-2 238.9 605.0
Acsl3 acyl-CoA synthetase long-chain family member 3 1 2.5 7.41E-4 6.2 15.7
Ace angiotensin I converting enzyme (peptidyl-dipeptidase A) 1 11 2.5 1.03E-2 1.5 3.9
Scd1 stearoyl-Coenzyme A desaturase 1 19 2.5 4.13E-2 3.1 7.8
Ldhb lactate dehydrogenase B 6 2.5 1.15E-2 8.9 22.4
Crb2 crumbs family member 2 2 2.5 3.34E-2 3.2 8.1
Scel sciellin 14 2.5 2.03E-2 12.3 30.8
Tsc22d1 TSC22 domain family, member 1 14 2.5 2.93E-3 30.2 74.8
Sod2 superoxide dismutase 2, mitochondrial 17 2.5 1.61E-3 3.0 7.4
Kcnk1 potassium channel, subfamily K, member 1 8 2.4 1.18E-3 7.4 18.2
Tmem106c transmembrane protein 106C 15 2.4 1.63E-2 3.4 8.3
Tenm4 teneurin transmembrane protein 4 7 2.4 1.61E-3 3.1 7.5
Gas6 growth arrest specific 6 8 2.4 4.05E-3 15.5 37.7
Tns2 tensin 2 15 2.4 2.76E-2 3.9 9.4
Cox7b cytochrome c oxidase subunit 7B X 2.4 1.90E-2 11.0 26.2
Vps41 VPS41 HOPS complex subunit 13 2.4 4.16E-3 2.7 6.3
Ddah2 dimethylarginine dimethylaminohydrolase 2 17 2.4 1.47E-2 5.2 12.3
Sort1 sortilin 1 3 2.4 1.25E-3 4.5 10.5
Cd99l2 CD99 antigen-like 2 X 2.4 1.13E-2 4.6 10.9
Gpc6 glypican 6 14 2.3 2.96E-2 1.8 4.3
Rfxap regulatory factor X-associated protein 3 2.3 4.49E-2 3.7 8.6
Ids iduronate 2-sulfatase X 2.3 1.57E-2 2.8 6.4
Tspan7 tetraspanin 7 X 2.3 7.47E-3 2.5 5.8
Efna5 ephrin A5 17 2.3 2.69E-3 5.0 11.6
Phactr2 phosphatase and actin regulator 2 10 2.3 9.39E-3 4.1 9.3
Nfia nuclear factor I/A 4 2.3 8.76E-3 2.7 6.1
Tmem94 transmembrane protein 94 11 2.3 2.35E-2 3.6 8.3
Yipf4 Yip1 domain family, member 4 17 2.3 8.43E-3 4.3 9.8
Ube2d-ps ubiquitin-conjugating enzyme E2D, pseudogene 11 2.3 3.94E-2 2.1 4.8
Cxxc5 CXXC finger 5 18 2.3 2.85E-3 5.6 12.8
Gpc4 glypican 4 X 2.3 5.44E-3 8.0 18.3
Mmut methylmalonyl-Coenzyme A mutase 17 2.3 4.60E-2 2.3 5.3
Zfp52 zinc finger protein 52 17 2.3 3.90E-2 2.1 4.7
Nek7 NIMA (never in mitosis gene a)-related expressed kinase 7 1 2.3 3.42E-2 2.4 5.5
Ptpn13 protein tyrosine phosphatase, non-receptor type 13 5 2.2 3.13E-4 2.3 5.1
Cst3 cystatin C 2 2.2 1.02E-2 64.4 144.5
Uqcr11 ubiquinol-cytochrome c reductase, complex III subunit XI 10 2.2 3.00E-2 8.7 19.5
Cadm2 cell adhesion molecule 2 16 2.2 2.19E-2 4.2 9.3
Phyh phytanoyl-CoA hydroxylase 2 2.2 7.59E-3 5.7 12.7
Insig1 insulin induced gene i 5 2.2 2.55E-2 6.7 14.8
Bcl6 B cell leukemia/lymphoma 6 16 2.2 3.22E-2 2.6 5.8
Fads1 fatty acid desaturase 1 19 2.2 9.88E-3 9.5 21.0
Gprc5c G protein-coupled receptor, family C, group 5, member C 11 2.2 3.13E-2 3.5 7.6
Pygb brain glycogen phosphorylase 2 2.2 9.93E-3 5.5 12.0
Gpalpp1 GPALPP motifs containing 1 14 2.1 3.35E-2 2.6 5.5
Etv5 ets variant 5 16 2.1 4.17E-2 5.9 12.5
Laptm4a lysosomal-associated protein transmembrane 4A 12 2.1 2.37E-2 25.8 54.1
Il11ra1 interleukin 11 receptor, alpha chain 1 4 2.1 3.52E-2 3.3 7.0
Dusp3 dual specificity phosphatase 3 11 2.1 1.35E-2 3.1 6.4
Slc7a11 solute carrier family 7 (cationic amino acid transporter, y+ system), member 11 3 2.1 1.33E-2 13.7 28.5
Igsf8 immunoglobulin superfamily, member 8 1 2.1 4.85E-2 3.4 7.1
Scrn1 secernin 1 6 2.1 4.56E-2 4.0 8.4
Prickle2 prickle planar cell polarity protein 2 6 2.1 1.23E-2 2.4 4.9
Axin2 axin 2 11 2.1 2.76E-2 3.3 6.9
Fdft1 farnesyl diphosphate farnesyl transferase 1 14 2.1 1.02E-2 5.0 10.3
Creg1 cellular repressor of E1A-stimulated genes 1 1 2.1 3.23E-2 5.9 12.1
Pdhx pyruvate dehydrogenase complex, component X 2 2.0 3.18E-2 3.1 6.4
Ndufb10 NADH:ubiquinone oxidoreductase subunit B10 17 2.0 4.16E-2 16.8 34.2
Arf6 ADP-ribosylation factor 6 12 −2.0 2.59E-2 66.5 32.9
Pprc1 peroxisome proliferative activated receptor, gamma, coactivator-related 1 19 −2.0 3.52E-2 18.2 9.0
Eif6 eukaryotic translation initiation factor 6 2 −2.0 4.24E-2 40.2 19.8
Sema4d sema domain, immunoglobulin domain (Ig), transmembrane domain(TM) and short cytoplasmic domain, (semaphorin) 4D 13 −2.0 6.13E-3 10.6 5.2
Noc2l NOC2 like nucleolar associated transcriptional repressor 4 −2.0 3.11E-2 47.6 23.4
Bcar1 breast cancer anti-estrogen resistance 1 8 −2.1 3.42E-2 33.2 16.2
Bach2 BTB and CNC homology, basic leucine zipper transcription factor 2 4 −2.1 1.66E-2 4.8 2.3
Ero1l ERO1-like (S. cerevisiae) 14 −2.1 1.47E-2 8.6 4.2
Cttnbp2nl CTTNBP2 N-terminal like 3 −2.1 4.67E-2 16.7 8.0
Abl2 v-abl Abelson murine leukemia viral oncogene 2 (arg, Abelson-related gene) 1 −2.1 8.19E-3 10.5 5.0
Trim25 tripartite motif-containing 25 11 −2.1 1.79E-2 14.3 6.8
Rapgef3 Rap guanine nucleotide exchange factor (GEF) 3 15 −2.1 6.66E-3 14.1 6.7
Card10 caspase recruitment domain family, member 10 15 −2.1 4.40E-2 17.6 8.4
Ccdc137 coiled-coil domain containing 137 11 −2.1 3.74E-2 8.1 3.8
Pttg 1ip pituitary tumor-transforming 1 interacting protein 10 −2.1 4.69E-2 26.7 12.6
Lrrfip2 leucine rich repeat (in FLII) interacting protein 2 9 −2.2 2.60E-2 26.0 12.1
Prtg protogenin 9 −2.2 1.35E-2 4.3 2.0
Tjap1 tight junction associated protein 1 17 −2.2 1.48E-2 12.5 5.8
Ppp1r15a protein phosphatase 1, regulatory subunit 15A 7 −2.2 9.93E-3 28.1 12.9
Ehd1 EH-domain containing 1 19 −2.2 1.57E-2 58.3 26.7
Vasp vasodilator-stimulated phosphoprotein 7 −2.2 4.84E-2 60.0 27.5
Erc2 ELKS/RAB6-interacting/CAST family member 2 14 −2.2 4.80E-2 8.3 3.8
Shb src homology 2 domain-containing transforming protein B 4 −2.2 1.02E-2 21.0 9.6
Vps37b vacuolar protein sorting 37B 5 −2.2 1.69E-2 15.1 6.9
Rnf217 ring finger protein 217 10 −2.2 2.27E-2 5.0 2.3
Sart3 squamous cell carcinoma antigen recognized by T cells 3 5 −2.2 5.32E-3 20.4 9.2
Eaf1 ELL associated factor 1 14 −2.2 3.56E-2 20.2 9.1
Ccdc9b coiled-coil domain containing 9B 2 −2.2 8.44E-3 33.4 15.1
Rhbdf2 rhomboid 5 homolog 2 11 −2.2 1.18E-2 12.0 5.4
Ftsj3 FtsJ RNA methyltransferase homolog 3 (E. coli) 11 −2.2 9.26E-3 24.7 11.1
Cdc42ep3 CDC42 effector protein (Rho GTPase binding) 3 17 −2.2 4.99E-2 8.7 3.9
Ctu2 cytosolic thiouridylase subunit 2 8 −2.3 4.81E-2 5.1 2.3
Litaf LPS-induced TN factor 16 −2.3 1.44E-2 15.0 6.6
Surf6 surfeit gene 6 2 −2.3 1.05E-3 13.9 6.1
Phldb1 pleckstrin homology like domain, family B, member 1 9 −2.3 2.42E-3 44.3 19.4
Igsf9b immunoglobulin superfamily, member 9B 9 −2.3 4.40E-2 4.9 2.1
Klhdc4 kelch domain containing 4 8 −2.3 2.33E-3 18.1 7.9
Tatdn2 TatD DNase domain containing 2 6 −2.3 1.60E-3 41.9 18.3
mt-Nd2 mitochondrially encoded NADH dehydrogenase 2 MT −2.3 4.41E-2 3117.5 1361.6
Nol10 nucleolar protein 10 12 −2.3 1.96E-2 22.2 9.6
Srf serum response factor 17 −2.3 1.06E-2 32.5 14.0
Urb2 URB2 ribosome biogenesis 2 homolog (S. cerevisiae) 8 −2.3 3.10E-2 5.0 2.1
Urb1 URB1 ribosome biogenesis 1 homolog (S. cerevisiae) 16 −2.3 3.88E-2 4.5 1.9
Smad7 SMAD family member 7 18 −2.3 1.18E-2 33.8 14.5
Trim47 tripartite motif-containing 47 11 −2.3 1.68E-2 24.3 10.4
Gprc5a G protein-coupled receptor, family C, group 5, member A 6 −2.3 3.13E-2 7.5 3.2
Epha2 Eph receptor A2 4 −2.4 3.62E-3 42.1 17.9
Zswim4 zinc finger SWIM-type containing 4 8 −2.4 1.02E-2 19.3 8.1
Mical2 microtubule associated monooxygenase, calponin and LIM domain containing 2 7 −2.4 7.81E-3 13.0 5.5
Tnfaip3 tumor necrosis factor, alpha-induced protein 3 10 −2.4 1.25E-3 20.7 8.7
Sh3bp2 SH3-domain binding protein 2 5 −2.4 4.84E-2 8.6 3.6
Kcnd3 potassium voltage-gated channel, Shal-related family, member 3 3 −2.4 1.30E-2 5.3 2.2
Kif7 kinesin family member 7 7 −2.4 4.84E-2 3.9 1.6
5430416N02Rik RIKEN cDNA 5430416N02 gene 5 −2.4 4.17E-2 4.8 2.0
Rnf213 ring finger protein 213 11 −2.4 1.10E-2 29.3 12.0
Rrp9 RRP9, small subunit (SSU) processome component, homolog (yeast) 9 −2.4 1.18E-2 16.3 6.7
mt-Nd4 mitochondrially encoded NADH dehydrogenase 4 MT −2.4 2.05E-2 1988.1 815.8
mt-Cytb mitochondrially encoded cytochrome b MT −2.4 2.34E-2 7413.0 3027.4
Tubb2b tubulin, beta 2B class IIB 13 −2.5 2.29E-2 18.9 7.6
Gm24187 predicted gene, 24187 13 −2.5 3.56E-2 3979.7 1607.5
Oasl2 2’-5’ oligoadenylate synthetase-like 2 5 −2.5 1.70E-3 18.5 7.5
mt-Nd6 mitochondrially encoded NADH dehydrogenase 6 MT −2.5 3.10E-2 851.8 342.4
Emilin2 elastin microfibril interfacer 2 17 −2.5 7.19E-3 25.2 10.0
Nbeal2 neurobeachin-like 2 9 −2.5 9.16E-3 4.9 2.0
Plec plectin 15 −2.5 4.68E-3 466.1 184.4
Snhg17 small nucleolar RNA host gene 17 2 −2.5 2.43E-2 4.0 1.6
Helz2 helicase with zinc finger 2, transcriptional coactivator 2 −2.5 4.29E-2 8.6 3.4
Klf16 Kruppel-like factor 16 10 −2.5 1.68E-2 7.9 3.1
Card19 caspase recruitment domain family, member 19 13 −2.5 3.75E-2 36.2 14.2
mt-Co1 mitochondrially encoded cytochrome c oxidase I MT −2.6 2.85E-2 6096.8 2387.9
Tnk2 tyrosine kinase, non-receptor, 2 16 −2.6 1.01E-3 25.7 9.9
Cd274 CD274 antigen 19 −2.6 4.85E-2 12.2 4.7
Gm8995 predicted gene 8995 7 −2.6 2.19E-2 5.0 1.9
Ier5 immediate early response 5 1 −2.7 8.19E-3 41.0 15.5
Ccdc88b coiled-coil domain containing 88B 19 −2.7 1.68E-2 15.2 5.7
Fmnl1 formin-like 1 11 −2.7 4.57E-2 30.6 11.5
Oaf out at first homolog 9 −2.7 9.13E-4 40.8 15.3
Pik3ap1 phosphoinositide-3-kinase adaptor protein 1 19 −2.7 5.32E-3 17.2 6.4
mt-Rnr2 mitochondrially encoded 16S rRNA MT −2.7 3.72E-2 111335.5 41317.1
Tcirg1 T cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 protein A3 19 −2.7 2.05E-2 24.3 8.9
Plk3 polo like kinase 3 4 −2.7 2.94E-2 17.3 6.3
mt-Rnr1 mitochondrially encoded 12S rRNA MT −2.8 3.49E-2 93896.8 33926.5
Il1rn interleukin 1 receptor antagonist 2 −2.8 3.15E-2 31.0 11.2
Slfn5 schlafen 5 11 −2.8 3.07E-2 6.6 2.4
Mtmr10 myotubularin related protein 10 7 −2.8 2.73E-3 15.6 5.6
Mertk MER proto-oncogene tyrosine kinase 2 −2.8 3.04E-3 10.2 3.7
Dot1l DOT1-like, histone H3 methyltransferase (S. cerevisiae) 10 −2.8 3.35E-4 28.6 10.2
Smox spermine oxidase 2 −2.8 1.09E-2 23.3 8.3
Pim1 proviral integration site 1 17 −2.8 2.04E-2 56.7 19.9
Syk spleen tyrosine kinase 13 −2.8 2.03E-2 11.0 3.9
Gm10925 predicted gene 10925 1 −2.9 4.84E-2 31.0 10.8
Rnf19b ring finger protein 19B 4 −2.9 3.42E-2 52.9 18.4
Lrrfip1 leucine rich repeat (in FLII) interacting protein 1 1 −3.0 1.16E-3 97.8 32.4
Dusp7 dual specificity phosphatase 7 9 −3.0 2.05E-3 38.0 12.5
Arl4d ADP-ribosylation factor-like 4D 11 −3.0 2.33E-3 36.9 12.1
Dimt1 DIM1 dimethyladenosine transferase 1-like (S. cerevisiae) 13 −3.1 7.97E-4 8.4 2.7
Gm48958 predicted gene, 48958 14 −3.1 2.86E-2 7.7 2.5
Cmtr2 cap methyltransferase 2 8 −3.1 1.24E-2 3.7 1.2
Nrg1 neuregulin 1 8 −3.1 4.11E-2 3.7 1.2
Fjx1 four jointed box 1 2 −3.1 3.42E-2 10.4 3.3
Thoc6 THO complex 6 17 −3.1 2.70E-2 9.9 3.2
Cdt1 chromatin licensing and DNA replication factor 1 8 −3.1 4.32E-2 10.3 3.3
Slc16a3 solute carrier family 16 (monocarboxylic acid transporters), 3 11 −3.2 1.30E-3 15.0 4.7
Elf3 E74-like factor 3 [ 1 −3.2 3.34E-2 9.7 3.0
Acod1 aconitate decarboxylase 1 14 −3.2 1.84E-2 24.6 7.6
Arhgap22 Rho GTPase activating protein 22 14 −3.3 1.34E-4 18.0 5.5
G0s2 G0/G1 switch gene 2 1 −3.3 1.13E-3 83.1 25.5
Csf3r colony stimulating factor 3 receptor (granulocyte) 4 −3.3 3.99E-3 51.9 15.7
Baiap2 brain-specific angiogenesis inhibitor 1-associated protein 2 11 −3.3 1.22E-2 11.3 3.4
Sp100 nuclear antigen Sp100 1 −3.3 2.74E-2 3.8 1.1
Sfn stratifin 4 −3.3 3.56E-2 14.4 4.3
Atf3 activating transcription factor 3 1 −3.4 3.50E-2 31.4 9.3
Srxn1 sulfiredoxin 1 homolog (S. cerevisiae) 2 −3.4 1.32E-2 67.9 20.0
Phlda1 pleckstrin homology like domain, family A, member 1 10 −3.4 3.60E-3 77.3 22.8
Chka choline kinase alpha 19 −3.5 1.41E-5 15.6 4.5
Tsc22d2 TSC22 domain family, member 2 3 −3.5 9.57E-6 27.5 7.9
Gm44899 predicted gene 44899 7 −3.5 4.35E-2 6.1 1.7
Ifrd1 interferon-related developmental regulator 1 12 −3.6 1.91E-3 22.2 6.1
Mxd1 MAX dimerization protein 1 6 −3.7 6.51E-3 37.5 10.2
Spata5l1 spermatogenesis associated 5-like 1 2 −3.7 4.45E-2 11.3 3.1
Pxdc1 PX domain containing 1 13 −3.8 4.39E-2 7.0 1.9
Dusp4 dual specificity phosphatase 4 8 −3.8 3.17E-2 20.4 5.4
Nefm neurofilament, medium polypeptide 14 −3.9 1.02E-2 12.4 3.2
Maff v-maf musculoaponeurotic fibrosarcoma oncogene family, protein F 15 −4.0 5.19E-4 20.6 5.2
H2-Q4 histocompatibility 2, Q region locus 4 17 −4.1 1.32E-2 36.4 8.9
Borcs6 BLOC-1 related complex subunit 6 11 −4.2 2.92E-2 4.8 1.1
Gadd45g growth arrest and DNA-damage-inducible 45 gamma 13 −4.3 2.45E-2 140.7 32.4
Kdelr3 KDEL endoplasmic reticulum protein retention receptor 3 15 −4.4 2.42E-3 10.0 2.3
Neat1 nuclear paraspeckle assembly transcript 1 (non-protein coding) 19 −4.4 9.13E-4 94.8 21.7
Gm36940 predicted gene, 36940 9 −4.7 4.29E-2 3.0 0.6
Ngf nerve growth factor 3 −4.8 3.94E-2 42.0 8.8
Ifi204 interferon activated gene 204 1 −5.0 1.71E-2 14.2 2.8
mt-Atp6 mitochondrially encoded ATP synthase 6 MT −5.0 1.23E-2 37.7 7.5
Rn7s2 7S RNA 2 12 −5.0 3.12E-3 101.4 20.2
Rbp4 retinol binding protein 4, plasma 19 −5.1 3.18E-2 6.5 1.3
Flnc filamin C, gamma 6 −5.8 3.35E-2 178.3 30.6
Cyp26a1 cytochrome P450, family 26, subfamily a, polypeptide 1 19 −6.0 1.01E-3 67.8 11.3
Mirt2 myocardial infraction associated transcript 2 15 −6.6 3.13E-2 4.3 0.7
Gm23833 predicted gene, 23833 17 −6.6 4.33E-3 29.7 4.5
Trpc6 transient receptor potential cation channel, subfamily C, member 6 9 −6.6 3.61E-3 4.3 0.7
Rsad2 radical S-adenosyl methionine domain containing 2 12 −7.1 2.01E-2 22.9 3.2
Gm26532 predicted gene, 26532 8 −7.8 3.35E-2 5.4 0.7
Tnfsf14 tumor necrosis factor (ligand) superfamily, member 14 17 −8.7 4.19E-2 3.2 0.4
Emp1 epithelial membrane protein 1 6 −9.2 4.95E-2 59.6 6.5
Oasl1 2’-5’ oligoadenylate synthetase-like 1 5 −9.7 3.62E-3 13.1 1.3
Mir3109 microRNA 3109 9 −9.9 2.92E-2 58.0 5.8
Muc5ac mucin 5, subtypes A and C, tracheobronchial/gastric 7 −10.2 2.97E-6 5.4 0.5
Cfap58 cilia and flagella associated protein 58 19 −11.3 6.99E-3 3.4 0.3
Foxn1 forkhead box N1 11 −11.7 2.93E-3 3.5 0.3
Asprv1 aspartic peptidase, retroviral-like 1 6 −13.9 6.66E-3 14.8 1.1
Klk9 kallikrein related-peptidase 9 7 −14.0 2.11E-2 3.7 0.3
Gm44275 predicted gene, 44275 6 −14.3 4.44E-2 3.2 0.2
Krt16 keratin 16 11 −16.8 4.29E-2 16.8 1.0
Krt17 keratin 17 11 −23.4 2.33E-3 18.3 0.8
Muc4 mucin 4 16 −25.4 1.74E-2 4.4 0.2
Gm9573 predicted gene 9573 17 −45.5 3.47E-2 3.1 0.1
Irx1 Iroquois homeobox 1 13 −69.9 2.76E-3 2.2 0.0
Krt12 keratin 12 11 −85.9 1.88E-4 6.9 0.1
C2cd4b C2 calcium-dependent domain containing 4B 9 −92.6 4.27E-4 7.0 0.1
Gm19219 predicted gene, 19219 9 −378.7 6.02E-3 3.8 0.0
Eif2s3y eukaryotic translation initiation factor 2, subunit 3, Y-linked Y −3251.2 1.75E-37 5.6 0.0
Kdm5d lysine (K)-specific demethylase 5D Y −4566.7 7.48E-42 2.2 0.0
Ddx3y DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked Y −7263.9 7.91E-63 10.1 0.0