Table 7.
DEGs between aged male and female lens fiber cells. Bold font denotes genes that have been previously reported to exhibit sex dependent expression in adult mouse tissues based on comparisons with SAGD (Shi et al., 2019). Italics font denotes genes that exhibit lens preferred expression in postnatal day 56 mouse lenses according to the iSyTe database (Kakrana et al., 2018).
| SYMBOL | DESCRIPTION | Chromosome | Fold Difference | FDR | Male FPKM | Female FPKM |
|---|---|---|---|---|---|---|
| Xist | inactive X specific transcripts | X | 2931.0 | 8.13E-82 | 0.0 | 23.5 |
| Prelp | proline arginine-rich end leucine-rich repeat | 1 | 25.0 | 4.15E-17 | 0.1 | 2.4 |
| Crygd | crystallin, gamma D | 1 | 23.1 | 4.48E-2 | 40.2 | 929.7 |
| Rbp3 | retinol binding protein 3, interstitial | 14 | 11.6 | 7.30E-3 | 0.4 | 4.4 |
| H2bc3 | H2B clustered histone 3 | 13 | 7.4 | 4.58E-2 | 0.4 | 3.4 |
| Ccnd2 | cyclin D2 | 6 | 5.9 | 4.21E-3 | 0.8 | 5.0 |
| Gm4865 | predicted gene 4865 | 5 | 5.6 | 4.60E-2 | 0.6 | 3.2 |
| Cxcl14 | chemokine (C-X-C motif) ligand 14 | 13 | 5.2 | 3.23E-5 | 0.9 | 5.1 |
| Ndufa4l2 | Ndufa4, mitochondrial complex associated like 2 | 10 | 3.6 | 2.04E-2 | 2.9 | 10.6 |
| Inhba | inhibin beta-A | 13 | 3.5 | 3.20E-2 | 1.7 | 5.8 |
| S1pr3 | sphingosine-1-phosphate receptor 3 | 13 | 3.1 | 1.44E-8 | 1.6 | 5.2 |
| Chrdl1 | chordin-like 1 | X | 3.1 | 5.19E-8 | 1.4 | 4.3 |
| Pdpn | podoplanin | 4 | 2.9 | 1.40E-9 | 7.8 | 22.4 |
| Aldh3a1 | aldehyde dehydrogenase family 3, subfamily A1 | 11 | 2.7 | 1.71E-5 | 53.1 | 143.0 |
| Gpsm2 | G-protein signalling modulator 2 (AGS3-like, C. elegans) | 3 | 2.6 | 4.42E-2 | 2.6 | 6.9 |
| Serping1 | serine (or cysteine) peptidase inhibitor, clade G, member 1 | 2 | 2.5 | 2.80E-3 | 1.6 | 4.1 |
| Slc7a8 | solute carrier family 7 (cationic amino acid transporter, y+ system), 8 | 14 | 2.4 | 2.41E-4 | 5.9 | 14.4 |
| Scarf2 | scavenger receptor class F, member 2 | 16 | 2.4 | 2.35E-2 | 2.0 | 4.8 |
| Notch2 | notch 2 | 3 | 2.3 | 1.46E-2 | 2.2 | 5.1 |
| Olfml2a | olfactomedin-like 2A | 2 | 2.3 | 1.63E-3 | 1.6 | 3.6 |
| Kcnk1 | potassium channel, subfamily K, member 1 | 8 | 2.3 | 1.06E-2 | 3.0 | 6.8 |
| Fez1 | fasciculation and elongation protein zeta 1 (zygin I) | 9 | 2.2 | 5.47E-3 | 1.7 | 3.8 |
| F2r | coagulation factor II (thrombin) receptor | 13 | 2.2 | 3.71E-2 | 1.6 | 3.6 |
| Msx1 | msh homeobox 1 | 5 | 2.2 | 4.92E-2 | 2.4 | 5.3 |
| Susd2 | sushi domain containing 2 | 10 | 2.1 | 7.67E-3 | 1.9 | 4.1 |
| Glul | glutamate-ammonia ligase (glutamine synthetase) | 1 | 2.1 | 6.38E-4 | 4.6 | 9.8 |
| Mme | membrane metallo endopeptidase | 3 | 2.1 | 3.08E-3 | 2.8 | 5.7 |
| Htra3 | HtrA serine peptidase 3 | 5 | 2.0 | 1.57E-2 | 4.7 | 9.5 |
| Bpgm | 2,3-bisphosphoglycerate mutase | 6 | −2.1 | 7.15E-3 | 5.6 | 2.7 |
| Guk1 | guanylate kinase 1 | 11 | −2.3 | 4.93E-2 | 8.6 | 3.7 |
| Zfyve21 | zinc finger, FYVE domain containing 21 | 12 | −2.8 | 1.30E-2 | 7.7 | 2.8 |
| Dmac1 | distal membrane arm assembly complex 1 | 4 | −3.4 | 3.23E-2 | 7.6 | 2.1 |
| Igfbp2 | insulin-like growth factor binding protein 2 | 1 | −11.4 | 6.82E-4 | 4.2 | 0.4 |
| Hba-a2 | hemoglobin alpha, adult chain 2 | 11 | −15.5 | 2.33E-4 | 63.2 | 4.1 |
| Col8a2 | collagen, type VIII, alpha 2 | 4 | −23.7 | 7.32E-12 | 2.6 | 0.1 |
| Hbb-bs | hemoglobin, beta adult s chain | 7 | −31.9 | 2.25E-3 | 28.7 | 0.9 |
| Eif2s3y | eukaryotic translation initiation factor 2, subunit 3, Y-linked | Y | −31.9 | 6.15E-10 | 4.2 | 0.2 |
| Alas2 | aminolevulinic acid synthase 2, erythroid | X | −43.2 | 2.55E-5 | 5.5 | 0.1 |
| Krt12 | keratin 12 | 11 | −44.1 | 1.33E-3 | 3.6 | 0.1 |
| Car3 | carbonic anhydrase 3 | 3 | −173.1 | 1.60E-3 | 6.4 | 0.0 |
| Ddx3y | DEAD (Asp-Glu-Ala-Asp) box polypeptide 3, Y-linked | Y | −408.7 | 1.56E-60 | 7.5 | 0.0 |