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. Author manuscript; available in PMC: 2022 Mar 23.
Published in final edited form as: Nat Nanotechnol. 2021 Sep 23;16(11):1251–1259. doi: 10.1038/s41565-021-00961-w

Fig. 1. Application of surface-fill hydrogel to complex surface cancer.

Fig. 1.

a, Surface-fill hydrogel (SFH) can be sprayed (or syringe-injected) into the pleural cavity as a primary treatment or adjuvant after surgical debulking of mesothelioma. SFH uniformly covers and fills complex tissue surfaces to effectively deliver miRNA nanoparticles to tumor cell foci. Cell entry and endosomal escape allows miRNA-mediated attenuation of genes important to oncogenesis. b, Two-stage process to prepare SFH. Nanoparticles are prepared in Stage 1 by complexing chemically modified double stranded miRNA to intrinsically disordered peptide. In stage 2, particles are subsequently encapsulated into a fibrillar hydrogel prepared by the triggered assembly of a second distinct peptide.