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. 2021 Nov 3;12:742610. doi: 10.3389/fmicb.2021.742610

FIGURE 1.

FIGURE 1

p4 is bactericidal in vitro against different strains of S. aureus and collaborates additively with peptide LL-37 in restricting S. aureus growth. (A) S. aureus strains 8325-4 and USA300 were incubated with the indicated concentration of p4 for 2 h. Cell viability in CFU/ml, shown as the percentage of killing for the indicated strain, was analyzed by MDA assay. (B) The indicated S. aureus strains were incubated with the indicated concentration of LL-37 for 2 h. Cell viability in CFU/ml, shown as the percentage of killing for the indicated strain, was analyzed by MDA assay. (C) The indicated S. aureus strains were incubated with 1.6 μM p4 and/or 0.6 μM LL-37 for 2 h. Cell viability in CFU/ml, shown as the percentage of control cells (bacteria incubated with PBS), was analyzed by MDA assay. Results are expressed as the mean ± SD of three independent experiments. ***p < 0.0001, ns, non-significant by one-way ANOVA with post hoc Tukey’s multiple comparison test.