Table 1.
Patient and tumor characteristics (N = 15).
| Characteristic, No of patients (%) | Data value |
|---|---|
|
| |
| Age at diagnosis, median (range), y | 58 (23–73) |
| Sex | |
| Male | 8 (53) |
| Female | 7 (47) |
| Smoking status | |
| Never smoker | 3 (20) |
| ≤10 pack-years | 1 (7) |
| >10 pack-years | 11 (73) |
| Alcohol consumption | |
| Never | 4 (27) |
| Social | 7 (47) |
| Misusea | 3 (20) |
| Primary tumor site | |
| Supraglottis | 12 (80) |
| Hypopharynx | 2 (13) |
| Undefined | 1 (7) |
| Stage at diagnosis b | |
| I-II (localized) | 3 (20) |
| III-IVB (locoregional) | 7 (47) |
| IVC (metastatic) | 5 (33) |
| Site of metastasis c | |
| Distant lymph nodes | 9/13 (69) |
| Bones | 6/13 (46) |
| Liver | 5/13 (38) |
| Lung | 5/13 (38) |
| Pathologic features | |
| Small cell neuroendocrine carcinoma | 8 (53) |
| Large cell neuroendocrine carcinoma | 3 (20) |
| Combined squamous cell carcinoma and small cell neuroendocrine carcinoma | 2 (13) |
| Undefined | 2 (13) |
a
Defined as >7 standard alcoholic drink per week for women and >2 for men, according to National Institute on Alcohol Abuse and Alcoholism
b
According to the AJCC 7th-edition TNM classification
c
First metastasis site. Included metastasis at diagnosis and metastasis that developed during follow-up.