Table S2. The results of multivariate Cox regression analysis.

Variable	HR	95%HR lower	OS			PFS
			95% HR higher	P value	HR	95%HR lower	95%HR higher	p-value
Age	1.020	1.003	1.038	0.022	1.009	0.994	1.025	0.236
Sex (Female/Male)	0.969	0.695	1.350	0.851	0.928	0.683	1.262	0.634
Race (White/Others)	1.017	0.682	1.517	0.935	0.907	0.616	1.336	0.621
T stage	1.334	1.085	1.641	0.006	1.281	1.042	1.574	0.019
N stage	1.521	1.242	1.862	0.000	0.891	0.722	1.099	0.281
M stage	1.565	0.792	3.093	0.198	1.102	0.501	2.425	0.809
Chemotherapy (Yes/No)	0.789	0.541	1.150	0.217	1.833	1.305	2.575	<0.001
Radiotherapy (Yes/No)	2.018	1.348	3.020	0.001	3.245	2.294	4.590	<0.001
Smoking history (No/Yes)	0.992	0.616	1.599	0.974	1.149	0.735	1.797	0.542
ZWINT expression level (Low/High)	1.601	1.147	2.234	0.006	1.485	1.079	2.045	0.015