Table 1.

Published studies of capsaicin for CHS in the ED.

Study	Design	Population	Main findings/conclusions
Biary et al. (2014) [3] (n = 1)	Case report	Adult	Resolution of N/V and abdominal cramping after 20–30 min
Lapoint J. (2014) [4] (n = 2)	Case series (abstract only)	Adolescent and adult aged 19 and 29 yo	Capsaicin cream associated with decrease in pain score from 8 to 4/10 and 3/10, respectively
Lapoint J. (2014) [4] (n = 5)	Case series (abstract only)	Adult	Resolution of nausea, vomiting, and pain within 22–45 min of administration of capsaicin
Roman et al. (2016) [6] (n = 1)	Case report	Adult	Metoclopramide and granisetron ineffective. Resolution of symptoms after application of capsaicin
Dezieck et al. (2017) [7] (n = 13)	Case series	Adults and adolescent aged 19 (n = 1) to 47 yo	Reported relief of symptoms within 45 min after administration of capsaicin cream
McCloskey et al. (2017)[8] (n = 22)	Retrospective cohort series (abstract only)	Ages unknown	Capsaicin associated longer emergency department length of stay (non-significant)
Graham et al. (2017) [9] (n = 2)	Case series	Adolescents aged 16 and 20 yo	Capsaicin associated with improvement in symptoms of nausea and abdominal pain
Hafez et al. (2017) [10] (n = 4)	Case series (abstract only)	Ages unknown	Patients discharged within hours of receiving capsaicin (also received ondansetron and prochlorperazine)
Moon et al. (2018) [11] (n = 1)	Case report (abstract only)	Adult	Partial resolution of symptoms after first application, complete resolution after 2 additional doses of capsaicin
Sharma U et al. (2018) [12] (n = 1)	Case report	Adult	4-day hospital admission; Droperidol, antacids, PPI’s and capsaicin associated with symptom improvement
Wagner et al. (2020) [13] (n = 43)	Retrospective cohort review	Adult	No significant difference in ED LOS when capsaicin was utilized for CHS 179 vs 201 min (p = 0.33)