Table 3.

Adjusted regression coefficients (95% confidence interval) from linear regression models for the time-specific associations between fluoride intake (0.5 mg/d) in pregnancy and Bayley-III neurodevelopmental outcomes at 12 (n=98) and 24 months (n=77).

	12 months (n=98)
	Cognitive			Language			Motor
Fluoride intake (mg/d)	β	95% CI		β	95% CI		β	95% CI
2nd Trimester (n=61)	−0.63	−3.03	1.79	−0.74	−3.22	1.74	−0.90	−3.07	1.28
3rd trimester (n=86)	−1.31	−3.64	1.03	−1.24	−3.57	1.10	−1.02	−3.36	1.32
Average in pregnancy (n=98)	−1.85	−4.18	0.49	−0.98	−3.21	1.25	−1.10	−3.28	1.08
Boys*	−2.43	−6.12	1.27	−1.04	−4.90	2.83	−0.72	−4.52	3.09
Girls*	−0.71	−3.50	2.09	−1.05	−3.95	1.84	−1.77	−4.62	1.08
P interaction term*	0.43			0.99			0.65
	24 months (n=77)
	Cognitive			Language			Motor
Fluoride intake (mg/d)	β	95% CI		β	95% CI		β	95% CI
2nd Trimester (n=43)	−0.62	−3.58	2.34	−0.92	−3.90	2.07	−1.65	−4.42	1.12
3rd trimester (n=71)	−1.26	−3.31	0.79	0.15	−1.93	2.24	−0.21	−2.29	1.87
Average in pregnancy (n=77)	−1.14	−3.26	0.99	−0.22	−2.34	1.91	−0.88	−3.02	1.26
Boys*	−3.50	−6.58	−0.42	−1.77	−5.02	1.47	−2.36	−5.67	0.95
Girls*	0.07	−2.37	2.51	0.70	−1.90	3.31	0.40	−2.24	3.04
P interaction term*	0.06			0.23			0.19

Models adjusted for motheŕs age, motheŕs education, SES, calcium intake (concurrent), added salt, gestational age, birth weight (z score), sex, breastfeeding practices.

^*Beta coefficients are presented for model with the interaction term sex*fluoride intake (3rd trimester), adjusted for motheŕs age, motheŕs education, SES, calcium intake (concurrent), added salt, gestational age, birth weight (z score), breastfeeding practices.

^*Bold font indicates p-value of interaction <0.10