Table 4.

Adjusted associations estimated from longitudinal mixed effects linear regression models of 0.5 mg/day fluoride intake in pregnancy and Bayley-III domains (12 and 24 months) with the effect modification of sex

Fluoride intake (mg/d)		Cognitive			Language			Motor
Trimester 2 (n=64)a		β	95% CI		β	95% CI		β	95% CI
	Boys	−1.72	−4.00	0.55	−0.34	−3.02	2.33	−2.01	−4.31	0.28
	Girls	0.24	−2.30	2.78	−2.32	−5.31	0.67	−0.41	−2.94	2.13
	P interaction term	0.24			0.31			0.34
Trimester 3 (n=91)b	Boys	−3.10	−5.67	−0.53	−1.84	−4.67	1.00	−1.70	−4.60	1.20
	Girls	−0.28	−2.26	1.70	0.10	−2.09	2.29	−0.16	−2.39	2.06
	P interaction term	0.07			0.26			0.38
Averaged (n=103)	Boys	−3.46	−6.23	−0.70	−0.81	−3.65	2.03	−2.12	−5.00	0.76
	Girls	−0.33	−2.53	1.88	−0.67	−2.95	1.61	−0.51	−2.80	1.78
	P interaction term	0.08			0.94			0.40

^aSample for 2^nd trimester may consist of a woman whose child was assessed at one (n=6) or both time points (n=58).

^bSample for 3^rd trimester may consist of a woman whose child was assessed at one (n=33) or both time points (n=58).

Models adjusted for Motheŕs: age, education, SES, calcium intake (concurrent); Infantś: gestational age and birth weight (z score), breastfeeding practices

Interaction: Sex (reference is boys) × Fluoride intake (mg/d), bolds indicates p-values <0.05