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. 2021 Nov 16;11:22340. doi: 10.1038/s41598-021-01752-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Phenolic compound bitter taste activity tests on hTAS2Rs. Relative fluorescence signals caused by phenolic compound activation of the receptors and the empty vector as a negative control. The concentration of the compounds used was [300 µM], except for Ligstroside aglycon and Oleuropein aglycon [200 µM], oleuropein that was [3 mM]. The asterisks indicate significant differences tested by one-way ANOVA (***p < 0.0001) (N = 2). Data represent mean ± SD.