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. 2021 Nov 16;12:6624. doi: 10.1038/s41467-021-26912-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Structure overview in a cartoon representation with gL in cyan, gH D-I in blue, D-II in wheat, D-III in green, D-IV in yellow, and 1D8 Fab in purple. The map is contoured at 1.2 RMS to show the density. b Zoomed-in view of the interaction between 1D8 and D-I and D-II. The key binding residue N310 of gH was indicated by a red star. c Cartoon representation of Fab 1D8 and other previously published Fabs AMMO1, CL40, and E1D1 bound to a single gH/gL molecule. The color scheme for gH/gL is as in (a) whereas 1D8 Fab in purple, AMMO1 Fab in light blue, CL40 Fab in pink, and E1D1 Fab in dark green. d Surface mapping of the four Fab epitopes on gH/gL with the same color in (c). Areas in black indicate the region where structural change was found upon binding to AMMO1 or CL40.