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. 2021 Nov 16;4:1289. doi: 10.1038/s42003-021-02805-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a The representative overlay images of brightfield and RFP channel of zebrafish embryos transplanted with RFP+ BT-549 cells at 2 days of post-treatment. b, c Quantitative data indicate the changes of tumor invasion (b) and burden (c) after the treatment. Tumor cell invasion was determined for the percentage of zebrafish xenografts that have tumor cells migrated away from the original injection site in each experimental repeat (a, b): n = 3–6. Tumor burden was quantified based on the fluorescence intensity using ImageJ 1.52a (a, c). Fish number for BT-549: n = 27 for vehicle and 20 for CPI-613, respectively; and Hs578T: n = 24 for vehicle and 22 for CPI-613, respectively. Scale bar = 0.5 mm. Statistical difference was calculated using an unpaired two-tailed t-test. *P ≤ 0.05, ***P ≤ 0.001.