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. 2021 Nov 16;11:22351. doi: 10.1038/s41598-021-01465-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Functional enrichment analysis using Metascape and GSEA. (a) Venn diagram showing overlapping RNAs detected via RNA-seq analysis of downregulated RNAs at 72-h post-transfection of either ASC (1) or (2) siRNA and relative to control siRNA-transfected PANC-1 cells. (b) Functional enrichment results. Heatmap showing the top 20 clusters colored according to the p-value (darker color indicates a lower p-value). (c) Network of the top 20 clusters of enriched terms. Each node indicates an enrichment term colored by cluster ID. Nodes sharing the same cluster are generally located in close proximity. Terms with a kappa similarity ≥ 0.3 are connected. (d) GSEA for the gene signature of KEGG_CELL_CYCLE. NES normalized enrichment score, FDR false discovery rate.