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Autophagy is essential for humanin-induced life span extension in worms.
Survival curves N2 (control) and HN (humanin transgenic) animals fed either control bacteria or bacteria expressing bec-1 dsRNA during adulthood. Mean lifespan was 24d for N2 control, 20 d for N2 bec-1 RNAi, 27d for HN control, and 22d for HN bec-1 RNAi , p <0.0001 (HN bec-1 RNAi vs HN control), p<0.01 (HN control vs N2 control), Log-rank (Mantel-Cox) test. This experiment was performed twice.
