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. Author manuscript; available in PMC: 2022 Nov 16.
Published in final edited form as: Vaccine. 2021 Oct 23;39(47):6817–6828. doi: 10.1016/j.vaccine.2021.10.042

Figure 4. Protection against RSV in cotton rats after single subcutaneous immunization with 107 pfu rVSV-pre-F, rVSV-HEK-pre-F, rVSV-post-F, or rVSV-F.

Figure 4.

Cotton rats were immunized with 107 pfu rVSV-pre-F, rVSV-HEK-pre-F, rVSV-post-F, or rVSV-F via subcutaneous route. After RSV-A2 challenge 4 weeks later, viral titers were assessed via TCID50, with the limit of detection at 2log10. Serum antibody levels were assessed via neutralizing antibody assay, with the limit of detection at 10. A. Neutralizing titers against RSV in serum. No recombinant generated neutralizing antibody titers. B. Lung homogenates. Immunization with all recombinants provided partial protection against RSV A2 challenge. C. Nasal turbinate homogenates. rVSV-pre-F immunization provided partial protection against RSV A2 challenge. * p<0.05, ** p<0.01, *** p<0.001, **** p<0.0001