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. Author manuscript; available in PMC: 2022 Nov 1.
Published in final edited form as: Drug Alcohol Depend. 2021 Aug 27;228:108985. doi: 10.1016/j.drugalcdep.2021.108985

Figure 1.

Figure 1.

Evaluation of sedative-motor effects (deep sedation, observable ataxia, rest/sleep posture) and species-typical behavior (passive visual, tactile/oral exploration, self-groom) in rhesus monkeys (N=4) prior to chronic alprazolam treatment (“Pre-Chronic Alprazolam”) tests and after ≥14 days of 6 mg/kg/day alprazolam (“During Chronic Alprazolam”). Alprazolam was administered i.v. and behavior was determined via focal observation sampling (5 min interval) conducted following the daily (~10:00 AM) injection. Observations were conducted by trained experimenters (see text for details) unaware of the treatments. Chronic alprazolam (1.0 mg/kg, i.v.) was administered via syringe pump 7 days per week, every 4 hours (6 mg/kg/day), via chronic venous catheters. Data are mean modified frequency scores ± SEM. “B”, baseline behavior scores with no injection, taken prior to any drug/compound exposures; “V” tests following vehicle injections. *Note that asterisks are acute (Pre-Chronic Alprazolam) test results vs. the same tests conducted during chronic administration (During Chronic Alprazolam), Bonferroni t-tests, p< 0.05.