Figure 2.

Evaluation of midazolam-induced sedative-motor effects (deep sedation, observable ataxia, rest/sleep posture) and changes in species-typical behavior (passive visual, tactile/oral exploration, self-groom) in rhesus monkeys (N=4) prior to chronic alprazolam treatment (“Pre-Chronic Alprazolam”) tests and after ≥14 days of 6 mg/kg/day alprazolam (“During Chronic Alprazolam”). Midazolam was administered i.v. instead of alprazolam (~10:00 AM) and behavior was determined via focal observation sampling (5 min interval). Other details as described in the caption for Figure 1.