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HZ-166-induced sedative-motor effects (deep sedation, observable ataxia, rest/sleep posture) and changes in species-typical behavior (passive visual, tactile/oral exploration, self-groom) in rhesus monkeys (N=4) prior to chronic alprazolam treatment (“Pre-Chronic Alprazolam”) tests and after ≥14 days of 6 mg/kg/day alprazolam (“During Chronic Alprazolam”). HZ-166 is an α2/3GABAA-subtype-preferring positive modulator. Other details as described in the caption for Figure 1.
