Table 2:

HR and 95% CI from Cox models with weighting

			Unweighted			Weighted			Weighted HR (95% CI)
Outcome	Group	# of Subjects	# of Events	PY	Rate	# of Events	PY	Rate	No Adj. for Pre	Adj. for Pre	Excluding Pre
Self-Harms	Opioid	17,45,199	801	19,76,599	4.05	872	19,88,414	4.38	1.28 (1.17–1.40)	1.27 (1.16–1.39)	1.36 (1.24–1.50)
	Benzodiazepine	3,96,894	708	4,41,836	16,02	431	4,17,981	10.31	3.01 (2.69–3.37)	3.01 (2.69–3.38)	3.22 (2.87–3.62)
	Op + Benzo	2,39,126	415	2,53,393	16.38	347	2,53,110	13.69	3.95 (3.50–4.47)	3.84 (3.40–4.34)	4.18 (3.69–4.74)
	None	23,81,219	701	30,09,182	2.33	1,018	30,42,743	3.34
Drug Overdose	Opioid	17,45,199	1,083	19,76,411	5.48	1,205	19,88,197	6.06	1.41 (1.31–1.53)	1.42 (1.31–1.53)	1.41 (1.30–1.53)
	Benzodiazepine	3,96,894	1,081	4,41,562	24.48	663	4,17,795	15.87	3.71 (3.37–4.07)	3.72 (3.38–4.08)	3.79 (3.45–4.17)
	Op + Benzo	2,39,126	712	2,53,221	28.12	577	2,52,978	22.80	5.28 (4.78–5.83)	5.20 (4.71–5.74)	5.36 (4.85–5.92)
	None	23,81,219	863	30,09,068	2.87	1,283	30,42,603	4.22
Self-Harms + Rx Overdose	Opioid	17,45,199	1,152	19,76,151	7.70	1,665	19,87,915	8.38	1.36 (1.27–1.45)	1.36 (1.27–1.45)	1.41 (1.31–1.51)
	Benzodiazepine	3,96,894	1,416	4,41,333	32.08	868	4,17,666	20.79	3.37 (3.11–3.66)	3.39 (3.13–3.67)	3.55 (3.27–3.86)
	Op + Benzo	2,39,126	878	2,53,114	34.69	727	2,52,882	28.74	4.61 (4.23–5.03)	4.51 (4.14–4.91)	4.82 (4.41–5.27)
	None	23,81,219	1,276	30,08,775	4.24	1,836	30,42,153	6.04
Accidental Drug Overdose	Opioid	17,45,199	3,601	19,74,529	18.24	3,661	19,86,350	18.43	1.63 (1.56–1.71)	1.63 (1.56–1.71)	1.63 (1.55–1.71)
	Benzodiazepine	3,96,894	1,611	4,41,223	36.51	1,199	4,17,446	28.73	2.55 (2.38–2.72)	2.55 (2.39–2.72)	2.56 (2.39–2.74)
	Op + Benzo	2,39,126	1,485	2,52,676	58.77	1,300	2,52,470	51.49	4.52 (4.24–4.82)	4.39 (4.11–4.67)	4.54 (4.25–4.85)
	None	23,81,219	2,751	30,07,581	9.15	3,357	30,41,006	11.04